CONCLUSION Italian Healthy Cath Lab study confirms that occupa- tional exposure to low dose ionizing radiation is a significant risk for development of cataract especially for IC. Monitoring eye lens and use of protective tools are crucial. CATEGORIES OTHER: Public Health Issues TCT-849 Radiation-Associated Lens Changes in the Cardiac Catheterization Laboratory: the IC-CATARACT (CATaracts Attributed to Radiation in the CaTh Lab) Initiative Aris Karatasakis, 1 Harilaos Brilakis, 2 Barbara Anna Danek, 3 Phuong-Khanh Nguyen-Trong, 4 Judit Karacsonyi, 5 Jose Roberto Martinez-Parachini, 6 Aya Alame, 7 Bavana Rangan, 8 Michele Roesle, 9 Charles Chambers, 10 Kenneth Rosenfield, 11 Roxana Mehran, 12 Subhash Banerjee, 13 Emmanouil Brilakis 14 1 Dallas VAMC and UT Southwestern, Dallas, Texas, United States; 2 Cosmos Eye Center, Athens, Greece; 3 Dallas VA Medical Center/UT Southwestern, Dallas, Texas, United States; 4 UT Southwestern, Dallas, Texas, United States; 5 UT Southwestern Medical Center, Dallas, VA North Texas Healthcare System, Dallas, Texas, United States; 6 University General Hospital of Ciudad Real. Spain; 7 Dallas VA Medical Center; 8 UT Southwestern Medical Center/ VA North Texas Health Care System, Dallas, Texas, United States; 9 Dallas VA Medical Center, Dallas, Texas, United States; 10 Hershey Medical Center, Hershey, Pennsylvania, United States; 11 Massachusetts General Hospital, Boston, Massachusetts, United States; 12 Zena and Michael A. Weiner Cardiovascular Institute at Mount Sinai School of Medicine, New York, New York, United States; 13 VA North Texas Health Care System, Dallas, Texas, United States; 14 VA North Texas Health Care System and UT Southwestern Medical Center, Dallas, Texas, United States BACKGROUND We sought to examine the prevalence and correlates of radiation-induced lens changes among interventional cardiology staff. METHODS We performed slit-lamp eye examination of participants at the 2016 Society for Cardiovascular Angiography and Interventions meeting. Radiation exposure and confounders were assessed using a survey. Lens changes were graded using a modified Merriam-Focht (MF) scale: 0 (no lens changes); 0.5 (pre-cataract); and 1.0 (frank opacity). RESULTS Of 117 participants, 99 reported occupational radiation exposure (89 cardiologists, 6 technicians,4 nurses); 18 non-exposed participants served as controls. The distribution of lens findings was: MF 0 in 57%, 0.5 in 30%, and 1.0 in 13%. As compared with controls, exposed participants were older (4911 vs. 3912 years, p<0.01) and had a higher prevalence of lens changes, but similar prevalence of frank opacities (Figure); age- and gender- adjusted odds for pre- cataract changes were higher in the exposed group (odds ratio: 5.3, 95% CI: 1.4-27.6). In the exposed group, participants with lens changes were older (5312 vs. 469 years, p<0.01), had longer exposure history (2112 vs. 1410 years, p<0.01), and were less likely to use radiation protection caps (11% vs. 27%, p¼0.04) and eyewear (45% vs. 62%, p¼0.09). CONCLUSION Occupational exposure to radiation was associated with higher prevalence of pre-cataract lens changes. The prevalence of clinically significant opacities was low and similar between groups. Larger longitudinal studies are needed to examine the long-term ef- fect of small doses of radiation on the lens. CATEGORIES OTHER: Public Health Issues TCT-850 Building of a network for the management of out of hospital cardiac arrest: experience of an italian mountainous region Francesca Tedoldi, 1 Simone Muraglia, 2 Giuseppe Braito, 3 Michele Dallago, 4 Alberto Menotti, 5 Filippo Zilio, 6 Roberto Bonmassari 7 1 S. Chiara Hospital, Trento, Trento, Italy; 2 Chiara- Trento, Italy; 3 SANTA CASA DE BELO HORIZONTE; 4 S.Chiara Hospital - APSS TRENTO - ITALY, TRENTO, Trento, Italy; 5 SANTA CASA DE BELO HORIZONTE; 6 Mount Sinai Medical Center; 7 Hospital S.Chiara, Trento, Trento, Italy BACKGROUND A new sensitivity is growing among the different specialists involved in the management of out of hospital cardiac ar- rest (OHCA), to offer the best therapies to pts from the event to hos- pital discharge. METHODS We evaluated mortality and neurologic outcome with Ce- rebral Performance Category score (CPCs) at discharge and 6-month mortality in a retrospective analysis of pts admitted to our hospital after return of spontaneous circulation (ROSC) and who underwent coronary angiography (CA) from 2012 to 2015. RESULTS 1089 OHCA were reported: 277 of these pts were admitted to our hospital after ROSC. 41 pts with a clear non-cardiologic cause of cardiac arrest were excluded. 162 pts (59%) with suspected cardiac origin underwent CA. 62 pts (26%) showed STEMI at the ECG after ROSC, 17 pts (7%) NSTEMI and 149 pts (63%) non-specific alterations (NSA). 8 were missing. 62 pts (38%) who underwent CA showed STEMI, 17 pts (11%) NSTEMI and 80 pts (49%) NSA. 3 were missing. 72/ 162 pts (44%) underwent PCI, 45 pts with STEMI,11 with NSTEMI and 16 with NSA. The mean number of vessels treated per pts was 1,showing a strategy of treating the culprit vessel only. The percent- age of no cerebral disability at discharge was good (CPCs 1) in 33% of pts in the global population admitted with OHCA, 46% (75/162 pts) in the group that underwent CA and 58% (42/72 pts) in the group un- derwent PCI. Mortality at discharge and at 6 months of the population with OHCA admitted at our hospital was 47% and 59% respectively. Mortality at discharge and at 6 months of pts that underwent CA and JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 68, NO. 18, SUPPL B, 2016 B343