E POSTERS JUVENILE IDIOPATHIC ARTHRITIS (JIA) P008 LIPID PROFILE DISORDERS IN CHILDREN AND ADOLESCENTS WITH JUVENILE IDIOPATHIC ARTHRITIS Samah I. Nasef 1 , Sara S. I. M. Abouzied 2 , Samar M. Elfiky 3 and A. Zeiton 3 1 Rheumatology Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt, 2 Paediatrics Department, Portfoad General Hospital, Portsaid, Egypt, 3 Paediatrics Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Background Dyslipidaemia is a well-recognized risk factor for cardiovascular diseases. Inflammation has been linked to alterations of the lipid profile and accelerated atherogenesis. Lipid profile disorders are one of the most studied problems in adult patients with rheumatoid arthritis. However, few studies addressed this problem in juvenile idiopathic arthritis patients. The objective is to describe the prevalence of dyslipidaemia in children and adolescents with Juvenile Idiopathic Arthritis. Methods One hundred patients diagnosed with JIA were included. Exclusion criteria were patients previously treated with lipid lowering drugs, history of familial dyslipidaemia, thyroid disease, and diabetes mellitus. Data obtained from the patients included age, gender, duration of disease and body mass index (BMI). Fasting lipid profiles included triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL). Fasting lipid profiles were measured after overnight fasting and consumption of normal diet for previous 2 days (without fat restriction). Normal values were considered according to reference values. Other laboratory tests included ESR, CRP, RF, and ANA. Disease activity was classified according to juvenile disease activity score (JADAS-27). Results The study included 100 JIA patients. Out of them, 78 patients were females, 51 patients had RF negative Polyarticular type, 20 patients had RF positive polyarticular type, 24 patients had systemic onset type and 5 patients had extended oligoarticular type. Mean age was 11.55  4.02 years. Mean age at disease onset was 8.3  1.5 years. Mean disease duration was 4.30  1.7 years. Mean BMI was 22.3  7.32 Kg/m2. Mean ESR was 31.24  10.4 mm/h. Mean CRP level was 7.56  4.61 mg/dl. About 20% of the patients had positive RF and about 8% had positive ANA. Twenty-six patients had active disease. Mean TC was 153.818  29.8 mg/dl, mean HDL was 47.65  16.8 mg/dl, mean LDL was 87.43  28.1 and mean TG was 89.04  26.1 mg/dl. The most common lipid abnormality was disturbed HDL, it was found in 40% patients followed by disturbed TG in 21% of patients. Abnormal TC was found in 15% of the patients and abnormal LDL was found in 12% of the patients. Active disease was significantly associated with abnormal TC, HDL, and TG levels (P ¼ 0.03  ), (P ¼ 0.03  ) and (P ¼ 0.04  ) respectively. No associations were found with ESR or CRP levels. Active disease is a significant risk factor for abnormal TG with increased risk of abnormal TG by 2.9 among cases with active disease than cases with inactive disease. The overall percent predicted was 73.8%. Conclusion Children and adolescents with JIA showed significant lipid profile abnormalities. Abnormal TC, HDL and TG are significantly associated with active disease. Active disease is a significant risk factor for abnormal TG. Therefore, we recommend monitoring lipid profile in JIA patients regularly to reduce the long-term risk of CVD. P009 OSTEOPOROSIS IS A FREQUENT COMPLICATION IN ENTHESITIS RELATED ARTHRITIS PATIENTS Hanene Ferjani 1 , Hiba Bettaieb 1 , Kaouther Maatallah 1 , Dorra Ben Nessib 1 , Wafa Triki 1 , Dhia Kaffal 1 and Wafa Hamdi 1 1 Rheumatology Department, Mohamed Kassab National Institute of Orthopaedics, La Mannouba, Tunisia Background Enthesitis related arthritis (ERA) represents a clinical entity of juvenile idiopathic arthritis. This chronic rheumatic disease may lead to early bone mass loss and increase risk fracture. The aims of this study were to evaluate the prevalence of clinical osteoporosis in patients with ERA and to identify what factors are associated with increased occurrence of osteoporosis. Methods We reviewed the medical records of patients with confirmed ERA. We analyzed their demographic data and the clinical characteristics. Dual- energy X-ray absorptiometry (DEXA) was used to determine bone status. Osteoporosis was defined as Z score <-2.5DS. Disease activity was evaluated by: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Data were analyzed using the SPSS statistical package. A P-value < 0.05 was considered significant. Results Thirty-three patients (27 male and 7 female) with a mean age at of 23.8  7.5 years were enrolled. The mean age at disease onset was 12  2.6 years. Median disease duration was 108 months [12–408]. The median ESR and CRP levels were 35 mm/h [8–90] and 20 mg/l [1–70] respectively. Median BASDAI score was 4.7 [1–9.7]. At bone densitometry, osteoporosis and osteopenia were found in 44.1% and 23.5% cases respectively. None of the patients had a history of osteoporotic fractures. Long term corticosteroid therapy and seden- tarily were noted in 18.2% and 47.1% of patients respectively. On statistical analysis, osteoporosis was associated with these para- meters: age at ERA onset (P ¼ 0.035), disease duration (P ¼ 0.04), CRP (P ¼ 0.009), BASDAI score (P ¼ 0.05) and sedentarily (P ¼ 0.031). Neither corticosteroid therapy (P ¼ 0.68) nor high ESR level (P ¼ 0.73) were associated with osteoporosis. Conclusion osteoporosis was a common extra articular feature As adult spondyloarthritis, disease activity, duration and seem to be associated with the bone loss. P010 CLINICO-EPIDEMIOLOGICAL CHARACTERISTICS AND OUTCOMES OF JUVENILE IDIOPATHIC ARTHRITIS (JIA) PATIENTS IN KENYA: DATA FROM THE KAPRI REGISTRY A. Migowa 1 , R. Odhiambo 1 , J. Orwa 1 and J. Shah 1 1 Aga Khan University Medical College East Africa Background Pediatric rheumatic diseases pose a significant disease burden upon children and their families (1–3). They lead to physical disability and diminished quality of life (1–3). Determination of the burden and clinical characteristics of these diseases is a critical first step to improving access to care and optimizing use of existing health systems for the well-being of these patients (4). This is in line with the goal of the Bone and Joint decade (2000–2010) aimed at increasing recognition and understanding of the impact of musculoskeletal diseases (5,6). The Kenya Pediatric Rheumatology Registry (KAPRI) offers a unique opportunity to pioneer and spearhead a systematic and organized format to inform policy and better healthcare provision. Our objective was to determine the patient characteristics, clinical features and outcomes of Juvenile Idiopathic Arthritis (JIA) patients assessed at the Aga Khan University Medical College East Africa from March 2019 to December 2020. Methods Data of JIA patients on age, gender, laboratory and clinical features at diagnosis and treatment options offered were extracted from the database. A further detailed chart review was undertaken to determine the proportion of patients who achieved remission or minimally active diseases. Results Among the 207 patients enrolled thus far, 16 (7.7%) were diagnosed to have JIA. Majority of the patients were females (75%; n ¼ 12) with a mean age of 7 years and 3 months (Range : 1 year—13 years 7 months). All patients had joint pain and swelling as the initial presenting complaints. Majority of the patients had polyarticular JIA (75%, n ¼ 12). The other 4 patients were oligoarticular (n ¼ 2) and systemic JIA (n ¼ 2). Among the polyarticular JIA patients (n ¼ 12), only 3 (25%) were rheumatoid factor (RF) positive and 1 was antinuclear antibody (ANA) positive. The oligoarticular and systemic JIA patients were all negative for antinuclear antibody, rheumatoid factor and cyclic citrullinated peptide antibodies (anti-ccp). Seven patients (43.8%) ß The Author(s) 2021. 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