formulation was subjected to further evaluation like Flow rate, Viscosity, Stability Studies. Thus an ideal Ayurvedic Suspension was formulated as per the Remingtons Law Of Pharmaceutics. In present scenario society is in need of an adaptable dosage form. Here plays the magnitude of modern technology adaptation by sticking on to the principles of Ayurveda. 18 161. A CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF AYURVEDIC TREATMENT IN PATIENTS WITH CEREBROVASCULAR ACCIDENT OF MORE THAN TWO YEARS DURATION V.C. Indulekha, V.N. Radhakrishnan, S.R. Chandra. Introduction: An around 50% stroke survivors need proper rehabilitation and is a big challenge to existing health care systems; especially after two or more years. Ayurvedic literature highlights the symptoms such as chestanivritti (difficulty in movements) and weakness of one side of the body along with ruja (pain) & vakstambha as Pakshaghata (Hemiplegia). Being a vata disorder, it has been managed with Snehana (unctuous sub- stances) snigdhasweda (sudation), mridushodhana (elimination therapies like purgation) and rasayanas (rejuvenators). Material and methods: 28 Diagnosed patients of CVA of more than two years duration, of both sex, age 4070 years included in the study and divided into two groups. The 15 patients in trial group was admitted in college hospital and given internal medicines like kashayam, Gulguluthikthaka grutham and treat- ment modalities like kayaseka, vasti (medicated enema) etc were done in all patients. The patients on modern medication and some exercises were kept as control group continued out patient consultation in Department of Neurology, Assessment was done with Activities of Daily Living (ADL) score-Barthel index at base level, 3 months and six months. Results and discussion: Out of 28 patients, 93% had hypertension, 32% had speech problems, 57% were independently mobile, 32% were using some walking aid, while one patient was bedridden due to bilateral CVA. Compared to control group, treated group showed good improvement in ADL score (p < 0.05), which might be due to Ayurveda treatment modal- ities by amplification neuronal and muscular functions. OA19 166. ANTI-PROLIFERATIVE EFFECTS OF AN HERBAL FORMULATED CREAM ON HUMAN KERATINOCYTES AND ITS IMPLICATION FOR PSORIASIS TREATMENT Baidyanath Mishra, Vivekanand Ramana, Sujata Mishra. Purpose: Psychosocial aspects are the current focus of research on chronic dermatoses. These aspects may contribute to exacerbation of psoriasis in 40 to 80% of cases, thus having great impact on patients' quality of life. Patients with psoriasis use specific coping strategies to deal with their skin disorder when compared to other patients with chronic skin disorders; they also present stress levels as high as the control group. The integration of results enables understanding the special state of mind experienced by psoriasis patients to deal with the condition, thus showing the urgent need to develop broader intervention strategies, which also involve the social and psychic dimensions. In the present study, we screened the study material for its anti-proliferative properties using cultured human HACAT keratinocyte cell model. Our experimental results suggest that I Psoridex Cream, designed by R & D Team of InnoVision Healthcare, is a promising source which can be effectively used as an herb-based topical agent for psoriasis treatment. Evidence is provided that inhibition of keratinocyte proliferation and improving skin hydration via induction of aquaporin-3 stimulation is the possible underlying mechanism for the observed anti- psoriatic action of study material. This study aims in coping strategies and to identify stress levels of patients with psoriasis. Methods: The test substance adopted is HACAT (Human, Keratinocyte). HaCaT (Human, Keratinocyte) Maintenance: Stock cells of HaCaT were cultured in DMEM supplemented with 10% inactivated Fetal Bovine Serum (FBS), penicillin (100 IU/mL), streptomycin (100 mg/mL) and amphotericin B (5 mg/mL) in an humidified atmosphere of 5% CO2 at 37  C until confluent. The confluent monolayer cultures (HaCaT) was dissociated using TPVG solution (0.2% trypsin, 0.02% EDTA, 0.05% glucose in PBS) and cells were sub-cultured by centrifugation. The stock cultures will be grown in 25cm 2 culture flasks. Preparation of culture for experiment: The confluent monolayer cultures were seeded at 1 x 105 cells/ml into the microtitre plate 96 well (Tarsons, India). The cultures were incubated in humidified atmosphere of 5% CO2 at 37  C until confluent. Results: I Psoridex cream showed low cytotoxicity with CTC50 value over 1000 mg/ml. Test substance exhibited moderate anti-proliferative prop- erty in a dose dependent manner over control. Anti-proliferative activity of test substances against HACAT cell lines at test concentration of 250 % stands 16.41% of anti-proliferation activity as compared to 9.34 % with dose of 125% of test concentration. Protein conc. of the test substance against HACAT cell line with 250 mg/mL at test dose yields Protein conc. (mg/mL) as 0.780, whereas for 125 mg/mL test does yields protein concentrate 0.8525. Conclusion: Collectively, the results of this study confirm that the study material, I Psoridex Cream, is capable of inhibiting mitotic proliferation rate in cultured HACAT keratinocytes. Given the targeting of keratinocyte as a relevant biological target, the observed anti-proliferative actions might probably provide the underlying mode of action of the test sub- stance and also rendering it as a promising therapeutic herb based candidate for treating psoriasis. OA20 168. CLINICAL AND IMMUNOLOGICAL OUTCOMES IN A CASE OF ALLERGIC ASTHMA THROUGH AYURVEDIC MANAGEMENT e A CASE REPORT S. Jyotish Jayandan, C. Mahesh Kundagol, James Chacko. Rationale: Ayurvedic Management on the basis of Tamaka Shwasa Chi- kitsa is able to bring about Immunomodulation in conditions of Allergic Asthma. This Case Report is the first of its kind in reporting Immuno- modulatory changes along with clinical changes in conditions of Allergic Asthma. Presenting concerns: A 27 year old lady approached Amrita Ayurveda Hospital with presenting complaints like Shortness of breath, wheezing since 2 months, expectoration of sputum since 5 months, occasional cough and was diagnosed as Allergic Asthma according to GINA criteria and was adviced IPD intervention. Interventions: She was managed with Amapachana with Trikatu Choorna followed by Snehapana with Shatpala Ghrita till attainment of Samyak Snigdha Lakshanas for 6 days. She was given three days of Sarvanga Abhyanga with Lavanayuktha Tila taila followed by Bhashpa Sweda and Virechana with Abhayadi modaka on the third day. She had Avara Shudhi with 6 Vegas. After her Samsarjana Krama she was given Chitrakahareetaki Lehya as Rasayana (Immunomodulator) for a period of one month and was further evaluated. Outcomes: Her post treatment results showed much changes in her symptoms and investigations like Serum IgE levels near normalised from 848 to 500, PEFR changed from 200 to 350 and Asthma Control Test changed from 20 to 24. Main lessons: Cost-effective and short span of Ayurvedic management can stabilize the Hypersensitivity condition in Allergic Asthma. Treatment has also brought about Immunological stability in the condition. Hence we understand that Allergic Asthma can be managed at both Clinical and Immunological levels through Ayurvedic management. OA21 173. EFFECTIVENESS OF AYURVEDIC TREATMENT IN ACUTE RENAL FAILURE IN BITES OF VIPERA RUSSELI e STUDY PROPOSAL FOR A RANDOMISED CONTROLLED TRIAL Preethi Mohan, Abhaya Kumar Mishra. Background: Acute renal failure (ARF) is the most common complication in bite of Vipera russeli. Simple low cost ayurvedic remedies can be a good alternative in ARF instead of directly going to peritoneal dialysis as in conventional methods. The aim of this study is to evaluate the effective- ness of ayurvedic treatment in treating ARF in patients with viper bites. Abstracts / Journal of Ayurveda and Integrative Medicine 9 (2018) S1eS30 S5