TECHNICAL REPORTS
2468
Concentrating diverse microbes in a time and cost effective
manner is an essential component in water quality monitoring
of recreational beaches. Historically, detection of bacteria and
viruses requires two different capture methods to detect both
types of organisms in a given water sample. Te purpose of this
present study was to evaluate a newly devised dual layered filtration
system, which was developed to simultaneously concentrate both
viruses and bacteria in one step from marine waters. An apparatus
was designed to accommodate two 90-mm diam., 0.45μm
pore size membranes in series, one on top of the other. Te top
polyvinylidene fluoride (PVDF) membrane was used to filter
bacteria by physical straining while the bottom HA membrane
retained viruses through adsorption. Results indicated that the
dual layer filtration system recovered 83 ± 14% of the test bacteria
(Enterococcus fecalis) and 81 ± 28% of the test virus (MS2 coliphage)
on the top and bottom membranes, respectively. Tis research
demonstrates the potential of using a dual layered filtration system
for the simultaneous concentration of both bacteria and viruses
on separate filters from recreational beach waters. Tis system is
relatively simple to use, inexpensive, and has the potential to be
suitable for routine monitoring. Tis study serves as a proof of
concept for the technique. Additional experiments are needed to
evaluate the system on a variety of different bacteria and viruses as
well as on water with different physical and chemical parameters.
Simultaneous Concentration of Enterococci and Coliphage from Marine Waters
using a Dual Layer Filtration System
A. M. Abdelzaher and H. M. Solo-Gabriele* University of Miami
C. J. Palmer University of Florida
T. M. Scott BCS Laboratories
I
ndicator microorganisms are currently used by regulatory
agencies to assess beach water quality. Although they may be
useful in most cases for establishing the quality of water, indicator
microbes are not necessarily protective of human health (Colford
et al., 2007). Tus, there is a need to expand current methods
used to assess water quality and this expansion can include direct
measurements for pathogens. One of the main obstacles in
establishing programs for pathogen monitoring is concentrating
water samples for the pathogens of interest as they are usually
found in low concentrations (Griffin et al., 2003). Ideally the
concentration method should isolate the three main classes of
pathogens (bacteria, protozoa, and viruses) simultaneously using
one standardized technique. Moreover, given the dilute quantities
of these pathogens, regulatory and research laboratories need to
have the ability to concentrate volumes larger than the traditionally
recommended 100 mL to allow for detection.
Te two main approaches currently used to concentrate bacte-
ria, protozoa, and viruses are size exclusion and membrane adsorp-
tion. Techniques based on the size-exclusion approach have shown
promising results in simultaneously concentrating all three classes
of organisms (Hill et al., 2005, 2007; Paul et al., 1991, 1996). Sev-
eral types of filters may be used in this approach including hollow
fiber and tangential flow filters. Tese filters may be blocked with
a solution such as calf serum or sodium polyphosphate to limit the
amount of microbes that will attach to the membrane (Hill et al.,
2005). Terefore microbes as well as all other particles above the
pore size of the membranes continue to circulate until the volume
decreases to <100 mL. Following this initial concentration a sec-
ondary concentration usually takes place to further decrease the
volume to <1 mL, an amount that can be analyzed by molecular
methods, that is, methods based on amplifying and simultaneously
quantifying targeted DNA/RNA molecules. Te advantage of this
approach is that large volumes of up to 100 L can be concentrated
using this method (Hill et al., 2007) and all classes of microbes are
concentrated since they are larger than the pore size used. Te dis-
advantage of this approach is that membranes may clog premature-
Abbreviations: CFU, colony forming units; PFU, plaque forming units; PVDF,
polyvinylidene fuoride; qPCR, quantitative polymerase chain reaction.
A.M. Abdelzaher, H.M. Solo-Gabriele, C.J. Palmer, and T.M. Scott, Univ. of Miami, Oceans
and Human Health Center, Key Biscayne, FL 33149. A.M. Abdelzaher and H.M. Solo-
Gabriele, Dep. of Civil, Architectural, and Environmental Engineering, Univ. of Miami,
Coral Gables, FL 33146-0630. C.J. Palmer, Dep. of Infectious Disease and Pathology,
Univ. of Florida, Gainesville, FL 32608. T.M. Scott, BCS Labs., Miami, FL 33155.
Copyright © 2009 by the American Society of Agronomy, Crop Science
Society of America, and Soil Science Society of America. All rights
reserved. No part of this periodical may be reproduced or transmitted
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without permission in writing from the publisher.
Published in J. Environ. Qual. 38:2468–2473 (2009).
doi:10.2134/jeq2008.0488
Published online 28 Sept. 2009.
Received 21 Nov. 2008.
*Corresponding author (hmsolo@miami.edu).
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Published November, 2009