Laya et al. Int J Cancer Clin Res 2021, 8:162 Volume 8 | Issue 5 International Journal of Cancer and Clinical Research Open Access Citaton: Laya A, Koubala BB, Pathak KP, Bueno V (2021) Vitamins and Provitamins Intake as New Insights to Prevent and/or to Treat breast Cancer: A Systemic Review. Int J Cancer Clin Res 8:162. doi. org/10.23937/2378-3419/1410162 Accepted: November 08, 2021: Published: November 10, 2021 Copyright: © 2021 Laya A, et al. This is an open-access artcle distributed under the terms of the Creatve Commons Atributon License, which permits unrestricted use, distributon, and reproducton in any medium, provided the original author and source are credited. Laya et al. Int J Cancer Clin Res 2021, 8:162 • Page 1 of 11 • DOI: 10.23937/2378-3419/1410162 ISSN: 2378-3419 Vitamins and Provitamins Intake as New Insights to Prevent and/or to Treat breast Cancer: A Systemic Review Laya A 1,2* , Koubala BB 2,3 , Pathak KP 4 and Bueno V 5 1 Department of Biological Sciences, Faculty of Science, University of Maroua, Cameroon 2 Department of Life and Earth Sciences, Higher Teacher’s Training College of Maroua, University of Maroua, Cameroon 3 Department of Chemistry, Faculty of Science, University of Maroua, Cameroon 4 Faculty of Social Science, Nepal Open University, Nepal 5 Center for the Study of Aging, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil *Corresponding author: Laya A, Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 46 Maroua, Cameroon, Tel: (+237)-653759511 Abstract Female Breast Cancer (BC) is the most diagnosed cancer across the world. The present systematic review aimed to update the new insights of vitamins and provitamins to prevent and/or to treat BC. Vitamins and provitamins are natural products that have been implicated to prevent and to treat BC. However, it is still scarce and non-consensual as reported in the literature. A systematic literature review was conducted to identify studies through PubMed, Medline, and AMBASE up to June 27, 2021 solely on the association between vitamins (or provitamins) and BC prevention or treatment. The related grey literature also was used. The results of 127 revelant publications after exclusion of 7715 papers revealed that natural vitamins and provitamis were used to prevent or to treat BC. It has been clear evidence that vitamins and provitamins reduce the risk of BC, which acting by various mechanisms with signifcant inverse efect and efective use in the treatment of BC. There is no indication for publication bias found, however there was high heterogeneity among studies. Despite its limitations, our systematic review provide the most comprehensive studies updated summary evidence to date on the association betweenvitamins, provitamins and BC prevention, treatment or therapeutic issues. The natural dietary of these nutrients may be encouraged among population in order to reduce the risk of BC. Thus, we hope that our publication will help for further investigation such as a large clinical trials to confrm the fndings of the present study. Keywords Breast cancer, Vitamins, Provitamins, Mechanism, Prevention ReseARch ARticLe Check for updates Introducton In the last decades, the World Health Organizaton states that cancer is the second leading cause of death worldwide among noncommunicable diseases. Worldwide, an estmated number of 19.3 million new cancer cases (18.1 million without skin cancer) occurred in 2020 [1]. The global cancer burden is expected to be around 28.4 million cases in 2040, hence as a 47% rise from 2020. Female Breast Cancer (BC) is the most common diagnosed cancer and surpassed lung cancer, with an estmated over 2.3 million new cases (11.7%) and with 6.9% deaths [1]. To date, almost more than two of every fve people can be develop cancer in their lifetme. The consumpton of dietary modifcatons are one of the most promising lifestyle changes that can adjust the risk of developing cancer from human by nearly 40% [2] and for this reason the diet-cancer linkages was studied over the past decades [3]. These studies have been showed high link with nutrients quality ingested by human. Thus, numerous studies have identfed some bioactve nutrients to prevent or to reduce risk of certain types of cancers during the life [4-8]. This suggest that agood diet, rich in fruits and vegetables which contain bioactve nutrients, is signifcant in the preventon of cancer development, which is in agreement with a large number of scientfc papers identfying a range of bioactve compounds