Dr Mahendra Bendre et al JMSCR Volume 04 Issue 06 June Page 11021 JMSCR Vol||04||Issue||06||Page 11021-11026||June 2016 Role of Single Dose Antibiotic Prophylaxis in Clean General Surgery Authors Dr Mahendra Bendre 1 , Dr Vinayak Kshirsagar 2 , Dr Prashant Male 3 , Dr Sarang Rathod 4 , Dr Shivmurti Khandalkar 5 1 Professor, D.Y. Patil Medical College, Pimpri, Pune-411018 Email: mahendrabendredr@gmail.com, Mobile no – 9561744365 2 Assistant Professor, D.Y. Patil Medical College, Pimpri, Pune-411018 Email: drvinusagar@yahoo.co.in, Mobile no. - 9850930621 3 Assistant Professor, D.Y.Patil Medical College, Pimpri, Pune-411018 Email: drprashant.male@gmail.com, Mobile no. - 7057145363 4 Senior Resident, D.Y.Patil Medical College, Pimpri, Pune-411018 Email: cr7.zizou.kaka@gmail.com, Mobile no. – 7769927522 5 Assistant Professor, D.Y.Patil Medical College, Pimpri, Pune-411018 Email: drshiva.khandalkar@gmail.com, Mobile no. - 9422636996 ABSTRACT Background – Postoperative wound infection is an important cause of morbidity in surgical patients and antibiotic prophylaxis forms one of the important preventive measures. Aims and Objectives – This study was performed in a major general hospital to establish the efficacy of antibiotic prophylaxis in clean general surgeries. Materials and Methods – The study was done in 100 cases divided in 2 groups, one of which was given a single dose of ceftriaxone within 2 hours of operative incision without any postoperative antibiotics and the other was given routine postoperative antibiotics. Postoperative evaluation was done for development of fever or wound infection. Observation and Results – Mean age was 35 and 33 in both groups while mean operative time was 45 – 53 minutes. Majority of cases performed were of hernioplasty. Various other factors such as length of incision, use of electrocautery and postoperative hospital stay were considered. Incidence of infection in both groups was similar but cost reduction of 88.11% was achieved in the first group. Conclusion – The restriction of antibiotic usage in preoperative period and omission of it in postoperative period didn’t result in increase in incidence of surgical site infection. However significant cost reduction is achieved in the cases where preoperative prophylactic antibiotics were used and hence can be advocated in clean general surgeries. Key Words: Preoperative, Antibiotic, Prophylaxis, Clean, Postoperative, Infection INTRODUCTION Postoperative wound infections have an enormous impact on patients’ quality of life and contribute substantially to the cost of patient care. It is a major source of morbidity and mortality in surgical patients. The potential consequences range from increased pain and care of an open wound to sepsis and even www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 5.88 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i6.56