TYPE Original Research PUBLISHED 06 January 2023 DOI 10.3389/fmed.2022.1008711 OPEN ACCESS EDITED BY Shuhei Hosomi, Osaka City University, Japan REVIEWED BY Ligia Sassaki, São Paulo State University, Brazil Yu Nishida, Osaka City University, Japan *CORRESPONDENCE Shabnam Shahrokh shabnamshahrokh@gmail.com Fateme Jodatfar f.jodatfar@gmail.com † These authors have contributed equally to this work and share first authorship SPECIALTY SECTION This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine RECEIVED 01 August 2022 ACCEPTED 05 December 2022 PUBLISHED 06 January 2023 CITATION Hatamnejad MR, Karvandi M, Jodatfar F, Ebrahimi N, Shojaeian F, Baradaran Ghavami S, Balaii H, Moeeni M, Rajabnia M, Shahrokh S and Asadzadeh Aghdaei H (2023) Evaluation of adalimumab effects on left ventricle performance by echocardiography indexes among patients with immunosuppressant refractory ulcerative colitis. Front. Med. 9:1008711. doi: 10.3389/fmed.2022.1008711 COPYRIGHT © 2023 Hatamnejad, Karvandi, Jodatfar, Ebrahimi, Shojaeian, Baradaran Ghavami, Balaii, Moeeni, Rajabnia, Shahrokh and Asadzadeh Aghdaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Evaluation of adalimumab effects on left ventricle performance by echocardiography indexes among patients with immunosuppressant refractory ulcerative colitis Mohammad Reza Hatamnejad 1† , Mersedeh Karvandi 2† , Fateme Jodatfar 3 *, Nastaran Ebrahimi 4 , Fatemeh Shojaeian 5 , Shaghayegh Baradaran Ghavami 1 , Hedieh Balaii 1 , Mahdi Moeeni 6 , Mohsen Rajabnia 7 , Shabnam Shahrokh 1 * and Hamid Asadzadeh Aghdaei 1 1 Department of Basic and Molecular Epidemiology of Gastrointestinal Disorders, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2 Department of Cardiovascular Imaging Research, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3 Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 4 Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 5 Department of Surgical Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6 Department of Cardiology, Seyed-ol Shohada Hospital, Urmia University of Medical Sciences, Urmia, Iran, 7 Non-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran Background and aims: Inflammatory bases lead to a simultaneous flourishing of cardiovascular complications with inflammatory bowel disease (IBD). As a released cytokine, tumor necrosis factor-α (TNF-α) can either disrupt or preserve cardiovascular performance. Due to this controversy, this study aimed to appraise the short-term anti-TNF (adalimumab [ADA]) relics on cardiac function by gauging the echocardiography indexes in patients with immunosuppressant refractory ulcerative colitis (UC). Methods: All cases with a definite diagnosis of UC were included based on providing written informed consent and owning the severe form of active disease (Mayo score ≥7), which did not dampen with immunosuppressant. Patients were excluded in the case of previous cardiac ailments/risk factors and prior related surgical or pharmaceutical intervention. Transthoracic echocardiography (TTE) was carried out before and 3 months after biological regimen allocation and changes in indexes [ejection fraction (EF), left ventricular end-diastolic volume (LVEDV)/left ventricular end-systolic volume (LVESV), and global longitudinal strain (GLS) in standard parasternal short axis from mid-ventricular level, two-, three-, and four-chamber apical long axes] were compared via statistical analyses. Frontiers in Medicine 01 frontiersin.org