486 Abstracts OBJECTIVES: To examine the disability and resource utilisation associated with osteo- and rheumatoid arthri- tis in five European countries. METHODS: A large international database was exam- ined to evaluate the disability and resource use in patients with rheumatoid and osteo-arthritis. The database in- cluded the Health Assessment Questionnaire (HAQ) Dis- ability Index, questions on satisfaction and questions on resource utilisation and lost work time. RESULTS: The Arthritis Disease Specific Programme, held by Adelphi Ltd, was used as the database for this study. It contains 4580 patient records, 4203 of which have self-reported HAQ data. HAQ data are reported for France (n = 609), Germany (n = 1079), Italy (n = 796), Spain (n = 1229), and the UK (n = 490). Patients with rheumatoid arthritis (n = 2022) consistently demonstrate more disability than those with osteoarthritis (n = 1836) (HAQ DI: 1.03 vs 1.01, respectively). Patients in the UK had the most RA and OA disability (HAQ DI 1.60 and 1.20, respectively). Within disease diagnoses, females had greater disability (1.08 vs 0.90 RA; 1.05 vs 0.95 OA). Pa- tients with RA tend to have more GP and specialist visits over six months compared to those with OA (3.30 and 1.79 vs 3.26 and 1.41), although OA patients tend to have more ED visits (0.14 vs 0.07). Self-reported days off work over six months were also greater for RA patients (25.44 vs 20.24). The greatest work absences were seen in the UK (RA: 45.00; OA: 41.10) and the least days off work were seen in Italy (RA: 7.09; OA: 4.24). CONCLUSIONS: OA and RA have large impacts on dis- ability and resource utilization in the European countries we examined. Although debilitating, the extent to which resources are consumed and work lost varies greatly from country to country. From this cross-sectional interna- tional database, RA patients have greater disability com- pared to OA. This is reflected by higher disability, greater resource utilisation, and more days off work. PAO10 PSYCHOMETRIC VALIDATION OF THE ARTHRITIS TREATMENT SATISFACTION QUESTIONNAIRE (ARTS) Trudeau E 1 , Pouchot J 2 , Hellot S 3 , Goguel J 4 1 Mapi Values, Lyon, France; 2 Hôpital Louis Mourier, Paris, France; 3 Mapi, Lyon, France; 4 Pfizer, Paris, France OBJECTIVE: To examine the reliability and validity of a new French questionnaire assessing patient satisfaction with their osteoarthritis (OA) treatment. METHODS: Item generation: Semi-structured interviews were performed among 20 osteoarthritis (OA) patients and 10 clinicians. Interviews were recorded, transcribed and an- alyzed. Content validity and cognitive debriefing of the first version of the Arthritis Treatment Satisfaction (ARTS) ques- tionnaire was evaluated by 10 OA patients. Validation study: Principal component analysis, multi-trait analysis, in- ternal consistency (Cronbach’s alpha) and known-group va- lidity were performed on a cross-sectional sample of 797 OA patients. Test-retest was assessed on 133 clinically sta- ble OA patients. Test-retest reliability was estimated with the Intraclass Correlation Coefficient (ICC). RESULTS: Patients were on average 67.5 years old (SD = 10.4), 64.5% were women, 26% had OA of the hip, 58% had OA of the knee, and all patients had suffered from OA for an average of 7 years (SD = 6.4). The re- sulting ARTS questionnaire comprised 18 items consist- ing of a clear four dimensional structure measuring advantages of treatment, treatment convenience, appre- hensions about treatment and satisfaction with medical care. Scores were calculated using the mean of items in each dimension. Cronbach’s alpha ranged from 0.63 for treatment convenience to 0.86 for advantages of treat- ment. ICC ranged from 0.61 for advantages of treatment to 0.75 for treatment convenience. ARTS significantly differentiated patients according to the presence of side effects, regular practice of physical activity, perceived pain and indices of severity. CONCLUSION: Results provide evidence for the good psy- chometric properties of this first treatment-satisfaction ques- tionnaire specific to osteoarthritis. The responsiveness of the ARTS questionnaire over time is still to be documented. PAO11 ECONOMIC ANALYSIS OF THE GUIDELINES FOR THE MANAGEMENT OF CORTICOSTEROID- INDUCED OSTEOPOROSIS IN RESPIRATORY PATIENTS Moore MR 1 , Boyter AC 1 , Walker A 2 1 University of Strathclyde, Glasgow, UK; 2 University of Glasgow, Glasgow, UK OBJECTIVE: To evaluate the economic efficiency of management guidelines for corticosteroid-induced os- teoporosis and establish whether it is more economically efficient to modify the guidelines when targeting respira- tory patients. METHODS: Data were collected from GP medical records related to osteoporosis risk factors and cortico- steroid use in the previous year. Sample data were used for economic modelling based on population data and costs from literature. Three strategies were evaluated: the existing guidelines; modified guidelines; treatment with- out reference to guidelines. Main outcome measures were net discounted cost per fracture averted and net dis- counted cost per quality adjusted life year (QALY) saved. RESULTS: A cohort of 110 (71 women) adult patients prescribed oral and/or inhaled corticosteroids was identi- fied. Following existing guidelines averted 0.5 fractures and saved 0.1 QALYs at a net total cost of £5,943. The resultant cost per fracture averted is £12,506 and cost per QALY saved is £40,356. When modified, to include in- termittent oral and inhaled corticosteroid use as risk fac- tors, the net total costs increased to £30,190, with 3.6 fractures averted and 1.1 QALYs saved resulting in a cost per fracture averted of £8,419 and cost per QALY saved of £27,854, representing greater economic efficiency. Fur-