Urine Protein Level In Pregnant Women Trimester Second And Third In Singaran Pati District Of Bengkulu City Zamharira Muslim Sahidan Syifa Alfa Rahma Program Study of Pharmacy Program Study of Health Analyst Program Study of Health Analyst Poltekkes Kemenkes Bengkulu Poltekkes Kemenkes Bengkulu Poltekkes Kemenkes Bengkulu Bengkulu, Indonesia Bengkulu, Indonesia Bengkulu, Indonesia zamhariramuslim@yahoo.com sahidan_labor@yahoo.com syifa763.sar@gmail.com I. ABSTRACT Proteinuria in pregnancy screening focused on the detection of plasma and renal glomerular filtration rate, and changes in pre-eclampsia as the most common cause of proteinuria in pregnancy. Protein urine exceeded the normal values caused by the hormone estrogen aldosterone and increased in pregnancy which causes fluid retention by the kidneys. The older age of the pregnancy, it will aggravate the leakage of protein in the urine. This study aims to reveal the protein levels in the urine of pregnant women trimester II and III. This research method descriptive with laboratory tests. The samples in this study were 23 pregnant women trimester II and III in Puskesmas Jembatan Kecil Singaran Pati, Bengkulu province. This study used random technique sampling. They were collecting data by measurement of urinary protein levels using acetic acid 6%. The results of the 23 respondents obtained 13 the pregnant women second trimester showed urine protein positive (+) for 2 persons (15.3%) whereas 10 pregnant women third trimester showed urine protein positive (+) for 2 persons (20.0%) and double positive (++) for 2 persons (20.0%) having the risk of preeclampsia in pregnancy. The incidence of proteinuria is more common in the third trimester pregnant women with higher levels of proteinuria. So for pregnant women are expected to increase knowledge about pregnancy tests further regularly and have a healthy life. Keywords: pregnant women, urinary protein, second trimester, third trimester. II. INTRODUCTION The risk of pregnancy is dynamic because pregnant women were initially normal, suddenly can be high-risk [1]. According to the World Health Organization (WHO) estimated the total number of women died that 10.7 million people due to give birth in 25 years from 1990 until 2015. In 2008, the incidence of pre-eclampsia worldwide ranged between 0.51% - 38.4% [2]. Maternal mortality in Indonesia is dominated by three major causes of death, namely, hemorrhage, hypertension in pregnancy and infections. The third proportion of maternal mortality has been changed, as bleeding and infection tended to decrease while increasing the proportion of hypertension. More than 30% of maternal deaths in Indonesia in 2010 caused by HDK that the cause of pre-eclampsia and eclampsia [3]. If viewed from the CFR (Case Fatality Rate), is the most significant cause of death eclampsia and pre-eclampsia with CFR 2.35%, although the percentage of cases is not as high as 4.91% of the total cases obstetric [4]. Eclampsia gives symptoms of edema, proteinuria, hypertension, and seizures in pregnancy. Hypertension in pregnancy is the leading cause of maternal deaths could be prevented by early detection through testing of proteinuria in pregnant women with antenatal [5]. Pre- eclampsia is more experienced by pregnant women in the third trimester of pregnancy or near the time of birth. Pre- eclampsia is more experienced by pregnant women older than 30 years and are under 20 years old and contains the first child or pregnant women who had a previous history of pre-eclampsia [6]. Based on data from Bengkulu City Health Department in 2016 maternal mortality rate (MMR) of Bengkulu was 91 per 100,000 live births with the number of deaths of 6 people. The number of maternal deaths in 2016 has decreased compared to the last three years, as the number of maternal deaths in 2015 was 15, in 2014 and 2013 were nine people [7]. Based on data from Bengkulu City Health Department in 2016 still a lack of awareness of pregnant women for antenatal diagnosis of diseases which 118 1st International Conference on Inter-Professional Health Collaboration (ICIHC 2018) Advances in Health Sciences Research (AHSR), volume 14 Copyright © 2019, the Authors. Published by Atlantis Press. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).