Treatment of Naturally Notoedres cati- infested Cats with a Combination of Imidacloprid 10 % / Moxidectin 1% Spot-on (Advocate ® / Advantage ® Multi, Bayer) S57 Klaus Hellmann 1 , Gabriele Petry 2 (*), Balazs Capari 3 , Dejan Cvejic 1 , Friederike Krämer 4 1 KLIFOVET AG, 80689 München, Germany 2 Bayer Animal Health GmbH, 51368 Leverkusen, Germany 3 Kapriol Bt., 8330 Sümeg, Hungary 4 Institute for Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Free University Berlin, 14163 Berlin, Germany Corresponding author: Gabriele Petry * E-mail: gabriele.petry@bayer.com Parasitol Res (2013) 112:S57–S66 DOI 10.1007/s00436-013-3281-y ECtoParasitEs Abstract Notoedric mange (feline scabies) is a rare, but high- ly contagious disease of cats and kittens caused by Notoedres cati (N. cati), which can infest other animals and also humans. The study objective was to determine the efficacy and safety of 10 % imi- dacloprid/1 % moxidectin (Advocate ® /Advantage ® Multi spot-on for cats) against natural N. cati infestation in cats. Sixteen cats were randomly assigned to treatment group or negative control using pre-treatment mite counts. The treatment group received a single spot on treatment of the investigational veterinary product (IVP) accord- ing to label instructions. The control group stayed untreated. Five cats from the negative control were treated with the IVP at the end of the study and observed for 28 days to increase the treatment group. Skin scrapings and mite counts were per- formed 28 days post treatment (p.t.). Notoedric skin lesion assessments with clinical scoring were per- formed regularly. Five animals had to be removed