Received: 13 October 2021 | Revised: 1 May 2022 | Accepted: 8 May 2022 DOI: 10.1002/htj.22597 ORIGINAL ARTICLE Numerical analogy of bioheat transfer and microwave cancer therapy for liver tissue Chaity Biswas 1 | Rehena Nasrin 1 | Muhammad S. Ahmad 2 1 Department of Mathematics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh 2 Higher Institution Centre of Excellence, UM Power Energy Dedicated Advanced Centre, University of Malaya, Kuala Lumpur, Malaysia Correspondence Rehena Nasrin, Department of Mathematics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh. Email: rehena@math.buet.ac.bd Abstract A numerical study of microwave cancer therapy for cylindrical‐shaped liver tissue with an elliptical‐shaped liver tumor has been carried out by this study. The time‐dependent electromagnetic wave and the bio‐heat transfer equations have been used as the governing equations and solved with appropriate boundary conditions using Galerkin's weighted residual scheme built‐in finite element method‐based COMSOL Multi- physics software. The coaxial applicator as well as the effects of different microwave input power levels (from 5 to 25 W), frequencies (from 0.7 to 5 GHz), and treatment time (from 0 to 1000 s) on hepatocellular carcinoma have been examined by this simulation and displayed graphically in terms of the microwave power dissipation, isothermal lines inside liver tissue, time‐ dependent profiles of temperature at different locations inside the tumor, specific absorption rate (SAR), and surface average transient temperature distribution of tumor tissue. The results demonstrate that microwave input antenna power and frequency have significant impacts on the temperature distribution and SAR values of liver tissue. When the microwave input power, as well as frequency, is increased, SAR and tissue temperature values also increase but the high Heat Transfer. 2022;1–28. wileyonlinelibrary.com/journal/htj © 2022 Wiley Periodicals LLC. | 1 Abbreviations: FEM, finite element method; LTNE, local thermal nonequilibrium; MCA, microwave coaxial antenna; MWA, microwave ablation; RF, radio frequency; RFA, radio frequency ablation; RFH, radio frequency heating; SAR, specific absorption rate; SWR, standing wave ratio; TEF, transverse electromagnetic field; TEM, transverse electromagnetic.