Available online at ScienceDirect www.sciencedirect.com Diabetes & Metabolism 40 (2014) 215–219 Short report Effects of adipose tissue distribution on maximum lipid oxidation rate during exercise in normal-weight women L. Isacco a,∗ , D. Thivel b , M. Duclos c,d,e,f , J. Aucouturier g , N. Boisseau b a Laboratory Culture Sport Health Society, EA 4660, and Exercise Performance, Health, Innovation Platform, Franche-Comte University, 25000 Besan¸ con, France b EA 3533, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions, Clermont University, Blaise Pascal University, BP 10448, 63000 Clermont-Ferrand, France c Department of Sport Medicine and Functional Explorations, Clermont-Ferrand University Hospital (CHU), G. Montpied Hospital, 63003 Clermont-Ferrand, France d INRA, UMR 1019, 63001 Clermont-Ferrand, France e University Clermont 1, UFR Medicine, 63001 Clermont-Ferrand, France f CRNH-Auvergne, 63001 Clermont-Ferrand, France g EA4488, Lille Nord de France University, “Physical Activity, muscle, Health”, 59790 Ronchin, France Received 11 January 2014; received in revised form 26 February 2014; accepted 27 February 2014 Available online 31 March 2014 Abstract Aim. – Fat mass localization affects lipid metabolism differently at rest and during exercise in overweight and normal-weight subjects. The aim of this study was to investigate the impact of a low vs high ratio of abdominal to lower-body fat mass (index of adipose tissue distribution) on the exercise intensity (Lipox max ) that elicits the maximum lipid oxidation rate in normal-weight women. Methods. – Twenty-one normal-weight women (22.0 ± 0.6 years, 22.3 ± 0.1 kg.m -2 ) were separated into two groups of either a low or high abdominal to lower-body fat mass ratio [L-A/LB (n = 11) or H-A/LB (n = 10), respectively]. Lipox max and maximum lipid oxidation rate (MLOR) were determined during a submaximum incremental exercise test. Abdominal and lower-body fat mass were determined from DXA scans. Results. – The two groups did not differ in aerobic fitness, total fat mass, or total and localized fat-free mass. Lipox max and MLOR were significantly lower in H-A/LB vs L-A/LB women (43 ± 3% VO 2max vs 54 ± 4% VO 2max , and 4.8 ± 0.6 mg min -1 kg FFM -1 vs 8.4 ± 0.9 mg min -1 kg FFM -1 , respectively; P < 0.001). Total and abdominal fat mass measurements were negatively associated with Lipox max (r = –0.57 and r = –0.64, respectively; P < 0.01) and MLOR [r = –0.63 (P < 0.01) and r = –0.76 (P < 0.001), respectively]. Conclusion. – These findings indicate that, in normal-weight women, a predominantly abdominal fat mass distribution compared with a pre- dominantly peripheral fat mass distribution is associated with a lower capacity to maximize lipid oxidation during exercise, as evidenced by their lower Lipoxmax and MLOR. © 2014 Elsevier Masson SAS. All rights reserved. Keywords: Women; Adipose tissue localization; Exercise; Metabolic fitness; Lipox max Abbreviations: A/LB, abdominal to lower-body; ANP, atrial natriuretic peptide; BMI, body mass index; CHO, carbohydrate; DXA, dual X-ray absorptiometry; FFA, free fatty acids; FFM, fat-free mass; FM, fat mass; H-A/LB, high abdominal to lower-body; L-A/LB, low abdominal to lower-body; MAP, maximum aerobic power; MLOR, maximum lipid oxidation rate; NW, normal-weight; SD, standard deviation; VCO 2 , carbon dioxide production; VO 2 , oxygen consumption; VO 2max , maximum oxygen consumption. ∗ Corresponding author. Laboratoire C3S, 31, chemin de l’Épitaphe, 25000 Besanc ¸on, France. Tel.: +33 3 81 66 67 16; fax: +33 3 81 66 68 36. E-mail addresses: laurie.isacco@univ-fcomte.fr, isaccolaurie@hotmail.com (L. Isacco), David.Thivel@univ-bpclermont.fr (D. Thivel), mduclos@chu-clermontferrand.fr (M. Duclos), Julien.aucouturier@univ-lille2.fr (J. Aucouturier), Nathalie.Boisseau@univ-bpclermont.fr (N. Boisseau). http://dx.doi.org/10.1016/j.diabet.2014.02.006 1262-3636/© 2014 Elsevier Masson SAS. All rights reserved. © 2021 Elsevier Masson SAS. Tous droits réservés. - Document téléchargé le 12/12/2021 Il est interdit et illégal de diffuser ce document.