Accepted Manuscript Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines Mikhail Krasavin, Anton Shetnev, Sergey Baykov, Stanislav Kalinin, Alessio Nocentini, Vladimir Sharoyko, Giulio Poli, Tiziano Tuccinardi, Mikhail Korsakov, Tatiana B. Tennikova, Claudiu T. Supuran PII: S0223-5234(19)30158-8 DOI: https://doi.org/10.1016/j.ejmech.2019.02.044 Reference: EJMECH 11136 To appear in: European Journal of Medicinal Chemistry Received Date: 25 January 2019 Revised Date: 10 February 2019 Accepted Date: 12 February 2019 Please cite this article as: M. Krasavin, A. Shetnev, S. Baykov, S. Kalinin, A. Nocentini, V. Sharoyko, G. Poli, T. Tuccinardi, M. Korsakov, T.B. Tennikova, C.T. Supuran, Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines, European Journal of Medicinal Chemistry (2019), doi: https://doi.org/10.1016/j.ejmech.2019.02.044. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.