How to cite: Ratmadewi, Ni Made Gitaria Sylvana., Rudy Dwi Laksono dan Laura Bianca Sylvia Huwae (2021) Gangguan Kognitif Pada Pasien Pasca Sembuh Dari Covid-19. Syntax Literate. 6(6). http://dx.doi.org/10.36418/ syntax-literate.v6i6.3151 E-ISSN: 2548-1398 Published by: Ridwan Institute Syntax Literate: Jurnal Ilmiah Indonesia p–ISSN: 2541-0849 e-ISSN: 2548-1398 Vol. 6, No. 6, Juni 2021 GANGGUAN KOGNITIF PADA PASIEN PASCA SEMBUH DARI COVID-19 Ni Made Gitaria Sylvana Ratmadewi, Rudy Dwi Laksono, Laura Bianca Sylvia Huwae Bagian Saraf Rumah Sakit Tingkat II Prof. dr. J.A Latumeten, Ambon Bagian Penyakit Dalam Rumah Sakit Tingkat II Prof. dr. J.A Latumeten, Ambon Email: madegitaria88@gmail.com, rudydwilaksono@gmail.com, laurahuwae@yahoo.com Abstract Patients recovering from Covid 19 have several complaints about memory. Corona virus could penetrate the CNS (Central Nervous System) and cerebrospinal fluid in less than a week. Histopathological examination of the brains of Covid-19 patients who died showed the potential for SARS-CoV-2 to infect the central nervous system (CNS). Neuro inflammatories can also damage BBB (Blood Brain Barier). Once BBB is disrupted, cytokines can enter the CNS and cause microglial activation and oxidative stress, leading to cognitive impairment. The research method was conducted in a cross-sectional of patients in the Covid-19 Isolation Room at the Level II Hospital. Prof. dr. J. A Latumeten Ambon during the period March 2020 to March 2021 interviews about Telephone Interview for Cognitive Status-M (TICS- M) which consisted of 22 questions with a total score of 50. Of the 167 patients, there were 54 patients who were willing to be interviewed and there were 28 patients with possible mild cognitive impairment with an age range 31-40 years. The results of this studyfound that the TICS-M scores in post-Covid 19 patients were related to age, but not related to sex and education. Keywords: cognitive impairment; covid-19; TICS-M Abstrak Pasien yang sembuh dari Covid-19 memiliki beberapa keluhan pada daya ingat. Virus corona dapat menembus ke SSP (Sistem Saraf Pusat) dan cairan serebrospinal dalam waktu kurang dari seminggu. Pemeriksaan histopatologi otak pasien Covid-19 yang meninggal menunjukkan potensi SARS-CoV-2 menginfeksi ke sistem saraf pusat (SSP). Neuro inflamasi juga dapat merusak BBB (Blood Brain Barier). Setelah BBB terganggu, sitokin dapat masuk ke SSP dan menyebabkan aktivasi mikroglial dan stres oksidatif, yang menyebabkan gangguan kognitif. Metode Penelitian dilakukan secara cross sectional random sampling terhadap pasien di Ruang Isolasi Covid-19 Rumah Sakit Tingkat II. Prof. dr. J.A Latumeten Ambon selama periode Maret 2020 sampai dengan Maret 2021 dengan melakukan wawancara menggunakan Telephone Interview for Cognitive Status-M (TICS-M) yang terdiri dari 22 pertanyaan dengan total nilai 50. Dari 167 pasien, terdapat 54 pasien yang bersedia di wawancara dan terdapat 28 pasien yang memiliki