Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 674 Priyanka et al. / Pharma Science Monitor 8(2), Apr-Jun 2017, 674-696 Pharma Science Monitor 8(2), Apr-Jun 2017 EVALUATION OF ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF ALBIZZIA LEBBECK BENTH. LEAVES IN RATS Chaudhari Priyanka R*, Vipul Gajera, Dhiren P. Shah Department of Pharmacology, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Bardoli. ABSTRACT To evaluate the Antiulcer activity of aqueous extract of Albizzia lebbeck .Benth leaves against Ethanol and Cysteamine HCL. induced Peptic Ulcer in rats. Antiulcer assays were performed using the protocols of ulcer induced by Ethanol and Cysteamine HCL. The aqueous extract of Albizzia lebbeck .Benth leaves were administered at doses 200 and 400 mg/kg.Omeprazole (20 mg/kg) was used as standard drug. Various parameters like ulcer index, SOD, MDA and CAT were also determined. Preliminary phytochemical investigation revealed the presence of Alkaloids, Saponins, Tannin, Phenolic compound and flavanoids. Pretreatment with omeprazole reduced the ulceration in ethanol and Cysteamine HCL induced models. AQAL at dose of 200 and 400 mg/kg inhibited ulcer formation in both models. However it was less compare to omeprazole. Oxidative stress marker (MDA) levels were found to be (11.45±0.241 mmole /gm of gastric tissue×10 -4 ) in the ethanol control group, which decreased to (10.04±0.098 mmole /gm of gastric tissue×10 -4 ), (9.493±0.318 mmole /gm of gastric tissue×10 -4) in the AQAL group 200mg/kg and 400 mg/kg respectively. Antioxidant parameters SOD and CAT activity were reduced significantly in the ethanol and Cysteamine HCL induced ulcerated group. Oral pretreatment with AQAL (200 and 400 mg/kg) significantly increased the SOD and CAT levels in both models. The histopathological study of the stomach and duodenum tissue also supported the above results. Overall data from our experimental studies suggest that aqueous extract of Albizzia lebbeck Benth. Leaves possess significant antiulcer activity and these actions of AQAL can be attributed to the phyto constituents like flavonoids, saponins tannins present in it. KEYWORDS: Antiulcer, Albizzia lebbeck Benth. leaves, Ethanol and Cysteamine HCL induced models, Omeprazole, Ulcer index, Antioxidant. INTRODUCTION Peptic ulcer disease is one of the common gastrointestinal disorders in clinical Practice. [1] Peptic ulcer occurs due to an imbalance between the aggressive (acid, pepsin, bile and Helicobacter pylori) and the defensive (gastric mucus and bicarbonate secretion, nitric oxide, prostaglandins, innate resistance of the mucosal cells) factors. [2] A localised loss of gastric as well as duodenal mucosa leads to the formation of peptic ulcer, a term that includes both gastric as well as duodenal ulcer. [3] Diverse factors such as alcohol consumption, stressful life, use of non-steroidal anti inflammatory drugs, Helicobacter pylori infections and smoking contribute to the PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com