_____________________________________________________________________________________________________ *Corresponding author: E-mail: tombari.monsi@ust.edu.ng, baribefe.koate@ust.edu.ng; International Blood Research & Reviews 13(4): 6-21, 2022; Article no.IBRR.87399 ISSN: 2321–7219 Serological Pattern of Hepatitis B Virus Infection and Risk Factors among Infected Individuals in Port Harcourt, Rivers State, Nigeria Baribefe Banavule Daniel Koate a* , Teddy Charles Adias b , Ebirien-Agana Samuel Bartimaeus c and Zacchaeus Awortu Jeremiah a a Haematology Unit, Department of Medical Laboratory Science, Rivers State University, Nkpolu- Oroworukwo, Port Harcourt, Nigeria. b Haematology Unit, Department of Medical Laboratory Science, Federal University Otuoke, Otuoke Bayelsa State, Nigeria. c Chemical Pathology Unit, Department of Medical Laboratory Science, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IBRR/2022/v13i430182 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/87399 Received 12 March 2022 Accepted 24 May 2022 Published 25 June 2022 ABSTRACT Hepatitis B virus infection is a serious global public health challenge that affects more than two billion people worldwide. This study aimed to evaluate the serological pattern of HBV infection in HBV infected patients in Port Harcourt, Nigeria. The main aim of this study was to evaluate the serological pattern of hepatitis B infection in Port Harcourt, Nigeria. This was a comparative cross sectional study carried out on 260 hepatitis B patients and blood donors attending hepatitis B clinics, and blood banks in Rivers State University Teaching Hospital, Port Harcourt, Military Hospital, Port Harcourt, and University of Port Harcourt Teaching Hospital, Choba. The study involved the use of hepatitis B panel assay, measurement of prevalence of hepatitis B virus infection in Port Harcourt, assessment of hepatitis B serological markers in all subjects, determination of the presence and prevalence of occult HBV among participants. HBV 5-parameter (panel) Rapid Test kit was used to assess HBV serological markers. Standard operation procedure, good laboratory practice, External/Internal Quality Control were used accordingly and Quality Assurance ensued. 84.2% Original Research Article