24–28 August 2008, Chicago, USA Oral poster abstracts to a Down baby. One patient did not have any invasive procedure following positive screening and had IUFD of a Down fetus occurred at 36 weeks. We did not observe any spontaneous fetal loss in all the other cases. Conclusions: Our data do not support the hypothesis that first trimester screening is likely to detect a large proportion of affected foetuses that would die spontaneously in utero. Although TOPs were performed early in pregnancy in our population, those cases with late diagnosis or TOP did not lead to spontaneous fetal loss in the interval. OP01.12 Karyotype and outcome of fetuses with increased nuchal translucency above 99 th percentile J. H. Chung, M. Y. Kim , J. H. Yang, H. M. Ryu, J. Y. Han, S. W. Lee Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Republic of Korea Objectives: The aim of this study was to determine the karyotyping results and course of pregnancy of fetuses with increased nuchal translucency (NT) above 99 th percentile from a routine obstetric population. Methods: A computerized ultrasonography database identified fetuses with increased NT above 99 th percentile at 11 + 0 ∼ 13 + 6 weeks of gestation from January 2005 through December 2006 in Cheil General Hospital. Among them, only cases with known pregnancy outcome were included in this study. We reviewed the medical records of these pregnant women and infants. Spontaneous abortion, intrauterine fetal death, abnormal karyotypes or finding of one or more major structural defects were assigned as an adverse fetal outcome. Results: During the study period, total 15.296 fetuses underwent routine ultrasonographic examination for NT measurement in our institute. Among them, 149 fetuses (0.97%) were increased NT above 99 th percentile. Excluding 41 cases of follow-up loss, 108 fetuses were included study population. Chromosomal abnormalities were present in 23.1% of cases (25/108), including 12 cases (48.0%) of Down syndrome. Major structural fetal malformations detected in 20-weeks level II sonogram were diagnosed in 13 of the remaining 83 cases (15.7%). The rate of adverse fetal outcome was 45.4% (49/108). In cases without other abnormal finding at routine NT examination (57 cases), Abnormal karyotypes were 7 cases (12.3%) and 45 infants with normal karyotype (90.0%) were born alive without major anomaly. Conclusions: Fetuses with increased NT above 99 th percentile requires more careful assessment of the fetus, with regard to both karyotyping and follow-up level II scan for detecting structural anomaly. In cases with isolated increased NT, more favorable outcome can be expected after exclusion of chromosomal anomalies. OP01.13 Are women satisfied with having had a first trimester combined risk assessment? L. B. Bangsgaard , A. Tabor Dept. of Fetal Medicine and Ultrasound, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Objectives: This study evaluated whether women made an informed choice about first trimester risk assessment, consisting of a double test and a nuchal translucency measurement, and were subsequently satisfied with their choice. Our hypothesis was that satisfaction would depend on whether the women had made an informed choice as well as on their combined risk estimate. Methods: Prospective questionnaire study in week 12 assessing the informed choice and in week 30 assessing satisfaction with having had a risk assessment performed. To assess whether women/couples made an informed choice about risk assessment, they completed a questionnaire based on MMIC, Multidimensional Measuremet of Informed Choice. A total of 546 women participated, 255 (47%) made an informed choice. A questionnaire was sent at 30 weeks’ gestation to women/couples regarding their satisfaction with choosing risk assessment. Couples with fetal chromosome abormalities were not contacted. We distinguished between spontaneously pregnant (SP) (n = 374; 85%) and pregnant by means of Assisted Reproductive Technology (ART) (n = 65; 15%). Using the Decisional Conflict Scale, developed and validated by Brehaut et al, the couples were asked to reflect on the decision of choosing risk calculation for Down’s syndrome. Results: 305 (82%)of the spontaneously pregnant women and 43(66%) of the ART women returned the questionnaire. Five (1.6%) of the SP women had regretted having the risk assessment done. All of them had negative attitudes and therefore had not made an informed choice. None of the ART women or any of the partners (both SP+ART) regretted. Regretted n = 5 (1.4%) Did not regret n = 343 (98.6%) p-value Informed Choice, 12 weeks’ gestation 0.064 Yes 0 161 (100%) No 5 (2.7%) 182 (97.3%) Attitudes, 12 weeks’ gestation 0.012 Positive 0 202 (100%) Negative 5 (3.4%) 141 (96.7%) Adjusted risk ≥ 1 : 300 0 13 (100%) 301–999 1 (5.6%) 17 (94.4%) ≤ 1 : 1000 4 (1.3%) 313 (98.7%) Conception Spontaneous 5 (1.4%) 300 (98.4%) ART 0 43 (100%) Age, years < 35 5 (2%) 240 (98%) ≥ 35 0 60 (100%) Medium length education/university No 2 (2.9%) 67 (97.1%) Yes 3 (1.1%) 276 (98.9) Conclusions: Although a large proportion of the population had negative attitudes towards risk assessment and did not made an informed choice in week 12, at 30 weeks’ gestation only few regretted having the risk assesssment. Of those regretting, all had negative attitudes. We did not find an association between risk estimate and regrets later in pregnancy. OP01.14 First trimester absent nasal bone to detect fetuses with Down syndrome. A Meta-analysis L. Tolaymat , L. Sanchez-Ramos, A. M. Kaunitz Obstetrics and Gynecology, University of Florida, Jacksonville, United States Screening for Down syndrome is an essential part of routine prenatal diagnosis. There is an accumulating literature showing evidence of the significance of absent fetal nasal bone in the first trimester in screening for Down syndrome. Objectives: To determine the accuracy of first trimester absent nasal bone in detecting Down syndrome in fetuses. Data Source: Articles published between January 1980 and December 2007 identified through a search of entries in electronic databases and references cited in original studies. Study Selection: Studies were included if they recorded first trimester findings of nasal bone presence or absence, and clinical outcome of Down syndrome. A total of 19 studies describing 77,961 unaffected Ultrasound in Obstetrics & Gynecology 2008; 32: 308–397 311