frontoparietal and occipitotemporal regions. Notably, no traces of such changes -differentiating the global topography of patients from HC- held when applying GSR. Conclusions: Our results (i) suggest that rsFC alterations detected stem from a global rather than a local source and (ii) corroborate the impact GS can exert on generating within and between- networks differences. Hence, we underline the necessity that future investigations on groups with expected altered topographical dis- tribution include GS within data-analysis and a proper evaluation of its involvement. Nonetheless, our results are in line with previous evidence of altered global topography in MDD. Hence, we inter- preted this finding as a benchmark of a whole-brain functional disbalance toward self-oriented cognition characterizing the trans- nosographic depressive syndrome. Disclosure of Interest: None Declared EPP0876 Self-compassion is associated with the superior longitudinal fasciculus in the mirroring network in healthy individuals M.-K. Kim 1 *, Y.-G. Hwang 2 , C. Pae 2 , C. R. Song 2 , M. Bang 2 , C. I. Park 2 and S.-H. Lee 2 1 Department of Psychiatry, CHA Ilsan Medical Center, CHA University, Goyang-si, Gyeonggi-do and 2 Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Korea, Republic Of *Corresponding author. doi: 10.1192/j.eurpsy.2023.1160 Introduction: Self-compassion (SC) describes an emotionally posi- tive attitude extended toward ourselves when we suffer, consisting of three main components; self-kindness, common humanity, and mindfulness (Germer & Neff, 2013). SC entails being warm and understanding towards ourselves when encountering pain or per- sonal shortcomings, rather than ignoring them or flagellating our- selves with self-criticism. SC also involves recognizing that suffering and failure are part of the shared human experience rather than isolating. In addition, SC requires taking a mindful approach to one’s feelings and thoughts, without judgment of them. Objectives: Self-compassion (SC) involves taking an emotionally positive attitude towards oneself when suffering. Although SC has positive effects on mental well-being as well as a protective role in preventing depression and anxiety in healthy individuals, few studies on white matter (WM) microstructures in neuroimaging studies of SC has been studied. Methods: Magnetic resonance imaging data were acquired from 71 healthy participants with measured levels of SC and its six subscales. Mirroring network as WM regions of interest were analyzed using tract-based spatial statistics (TBSS). After the WM regions associated with SC were extracted, exploratory correlation analysis with the self-forgiveness scale, the coping scale, and the world health organization quality of life scale abbreviated version was performed. Results: We found that self-compassion scale (SCS) total scores were negatively correlated with the fractional anisotropy (FA) values of the superior longitudinal fasciculus (SLF) in healthy individuals. The self-kindness and mindfulness subscale scores of SCS were also negatively correlated with FA values of the same regions. The FA values of SLF related to SC were found to be negatively correlated with the total scores of self-forgiveness scale, and self-control coping strategy and confrontation coping strategy. Conclusions: Our findings suggest that levels of SC and its self- kindness and mindfulness components may be negatively associ- ated with DMN-related WM microstructures in healthy individ- uals. These less WM microstructures may be associated with positive personal attitudes, such as self-forgiveness, self-control and active confrontational strategies. Disclosure of Interest: None Declared EPP0877 Resting-state brain activity dysfunctions in schizophrenia and their associations with negative symptom domains P. Pezzella 1 *, G. M. Giordano 1 , L. Fazio 2 , L. Giuliani 1 , A. Mucci 1 , P. Bucci 1 , M. Amore 3 , P. Rocca 4 , A. Rossi 5 , A. Perrottelli 1 , E. Caporusso 1 , A. Bertolino 6 , S. Galderisi 1 and M. Maj 1 1 Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples; 2 LUM - Libera Università Mediterranea “Giuseppe Degennaro”, Bari; 3 Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa; 4 Department of Neuroscience, Section of Psychiatry, University of Turin, Turin; 5 Department of Biotechnological and Applied Clinical Sciences, Section of Psychiatry, University of L’Aquila, L’Aquila and 6 Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy *Corresponding author. doi: 10.1192/j.eurpsy.2023.1161 Introduction: Negative symptoms represent a fundamental aspect of schizophrenia: they have a substantial impact on patients’ real- life functioning and do not respond satisfactorily to currently available treatments. Therefore, a better understanding of the pathophysiological mechanisms underlying these symptoms could favor the development of new treatments. To date, the most validated pathophysiological hypothesis indicates an association between the Motivational domain (consisting of avolition, anhedonia and asociality) and alterations in the neuronal circuits involved in motivation. The Expressive Deficit domain (consisting of blunted affect and alogia) would be subtended by widespread alterations of cortical connectivity and associated with impaired neurocognition, social cognition, and the presence of neurological soft signs. Objectives: The aim of the present study is to examine the neuro- biological correlates of the two domains of negative symptoms, starting from the brain areas that have been most commonly found in the literature to be associated with negative symptoms. Methods: Resting-state (rs) fMRI data were acquired in 62 subjects with schizophrenia (SZ) and 46 healthy controls (HC). The two negative symptom domains were assessed using the Brief Negative Symptom Scale. In addition, the following assessment tools were used: the Positive and Negative Syndrome Scale for the assessment of positive symptoms and disorganization, the Calgary Depression Scale for Schizophrenia for depression and the St. Hans Rating Scale for extrapyramidal symptoms. The study of the possible relation- ships between rs-brain activity and the negative symptoms domains S550 e-Poster Presentation https://doi.org/10.1192/j.eurpsy.2023.1161 Published online by Cambridge University Press