GW29-e0925 Anthropometric measurements – Predictors of Major Adverse Events in Non-ST Elevation Myocardial Infarction Patients and their Survival – a Cohort study Sajjad Ali, Sherbahadar Khan, Zohaibullah Zahid, Muhammadsaad Jibran Lady Reading Hospital, Pakistan OBJECTIVES The objectives of this study is to determine the anthropometric measurement that best associated with angiographic severity and best predictor of major adverse cardiovascular and ce- rebrovascular event in patients who are successfully re-vascularized after non-ST elevation myocardial infarction. METHODS This is a prospective cohort study done in Cardiology unit, Lady Reading Hospital, Peshawar from 1 st July, 2016 to 31 st December, 2017. Cohort was selected on the basis of complete revascularization after non-ST elevation MI in the first 6-months period and were followed over a period of 12 months with a 3- months clinical and monthly telephonic follow-up, to observe for any major adverse cardiovascular and cerebrovascular events (MACCE). Raised level of BMI, waist, wrist, neck circumferences and waist-to-hip ratio were defined as >25 kg/m2, >102cm & >88cm, >20cm & >18cm, 40cm & 37cm for male and female, and 0.55 ratio respectively. Chi-square test used to correlate anthropometric values with angiographic severity and incidence of MACCE. Logistic regression model was applied for prediction of MACCE. Kaplan-Meier curve used for survival of these patients through one year. RESULTS Total of seventy three patients having successful revas- cularization after NSTEMI, with a mean age of 59.25  10.34 years were enrolled in the study. Of these 47.9% were males. 31 (42.4%) patients had triple vessel disease. Neck circumference is best correlated with angiographic severity (X 2 ¼ 22.59) followed by BMI (X 2 ¼ 22.2) with significant P-value for all except for waist circum- ference. Similarly, all were associated with incidence of MACCE, with WrC as the best (X 2 ¼ 16.12) followed by NC. Relative risk for occurance of MACCE was with NC (RR¼4.5) and also, NC best pre- dicts MACCE. Kaplan Meier curves show significant correlation of raised anthropometric values with incidence of MACCE i.e. all pa- tients who had MACCE had raised anthropometric values except for two cases who had normal WrC. CONCLUSIONS Raised anthropometric values are significantly asso- ciated with angiographic severity (NC as best) and incidence of MACCE (WrC as best) in NSTEMI patients, with the neck circumfer- ence as its best predictor. Follow-up of these patients show similar significant results for MACCE occurance. GW29-e0991 Effect of Atorvastatin and Trimetazidine Combination Treatment in Patients with Non-ST Segment Elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Jiangyou Wang, Hua Yan, Xi Su Wuhan Asia Heart Hospital OBJECTIVES Our study sought to assess the effect of atorvastatin (ATV) and trimetazidine (TMZ) combination treatment in patients with non-ST segment elevation acute coronary syndromes (NSTE- ACS) undergoing percutaneous coronary intervention. METHODS 250 patients with NSTE-ACS who were undergoing percutaneous coronary intervention (PCI) were enrolled in this study. Standard secondary prevention of coronary heart disease drug treatment was administered to both groups (the ATVþTMZ group and the ATV group). In the ATVþTMZ group, patients were orally 80mg 12h before PCI, with a further 20mg every day to 30th days after PCI and 60mg 30min before PCI, with a further 20mg tid to 30th days after PCI. In the ATV group, patients were only orally 80mg 12h before PCI, with a further 20mg every day to 30th days after PCI. Echocardiography was executed and plasma N-terminal pro brain natriuretic peptide (NT-pro-BNP) levels were measured just prior to the PCI and 30th days after PCI. The major cardiovas- cular events (MACE) were also evaluated in both groups 30th days after PCI. RESULTS Major adverse cardiac events occurred in 14.17% of pa- tients in the ATV group and 6.50% of those in the ATVþTMZ group (P¼0.047). NT-pro-BNP of the two groups were decreased 30th days after PCI, however, NT-pro-BNP in the ATVþTMZ group were significantly lower than those in the ATV group (P<0.05). Cardiac function in NSTE-ACS patients, as reflected by the increased LVEF, FS as well as decreased LVEDd (P<0.05) in all groups at 30 days after intervention, but cardiac function parameters were more obviously improved in the group administered with ATVþTMZ (p<0.05). CONCLUSIONS Our study suggests that short-term pretreatment with the combination of ATV and TMZ administration prior to PCI could reduce the incidence of MACE, and prominently decrease NT-pro-BNP and improve cardiac function compared to a single administration of the ATV. GW29-e1000 Reperfusion therapy and antithrombotic treatments in patients 75 years and older with ST-segment elevation myocardial infarction in China: findings from the CCC-ACS Project Mengge ZHOU, 1 Jing Liu, 1 Yongchen Hao, 1 Gregg C. Fonarow, 2 Junbo Ge, 3 Kathryn A. Taubert, 4 Louise Morgan, 5 Changsheng Ma, 6 Yaling Han, 7 Sidney C. Smith, JR., 8 Yong Huo, 9 Dong Zhao 1 1 Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; 2 Division of Cardiology, Geffen School of Medicine at University of California, Los Angeles, CA, USA; 3 Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; 4 Department of International Science, American Heart Association, Basel, Switzerland; 5 International Quality Improvement Department, American Heart Association, Dallas, TX, USA; 6 Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China; 7 Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, Liaoning, China; 8 Division of Cardiology, University of North Carolina, Chapel Hill, NC, USA; 9 Department of Cardiology, Peking University First Hospital, Beijing, China OBJECTIVES With population aging and the extension of life ex- pectancy, the proportion of patients  75 years of age with ST-segment elevation myocardial infarction (STEMI) is expected to increase. As these elderly patients are at high risk of both ischemia and bleeding, giving the appropriate treatment to those patients has always been the challenge of cardiologists. Reperfusion therapy and antithrombotic treatments are key treatments of these patients, but few studies reported status of these treatments in patients  75 years. In this study, we aimed to evaluate reperfusion therapy and antithrombotic treatments in patients  75 years with STEMI in China. METHODS The Improving Care for Cardiovascular Disease in China Project - ACS program is a nation-wide registry study, which was launched in 2014 as a collaborative study of the American Heart As- sociation and Chinese Society of Cardiology. Between November 2014 to June 2017, a total of 6841 STEMI patients 75 years from 150 participating hospital were included in this study. Characteristics and clinical management of these patients were collected by a standard web-based data collection platform. RESULTS Among these STEMI patients 75 years, the average age was 80.0 (4.1) years and 59.9% were male. Overall, 208 (3.0%) of patients received thrombolysis therapy in the first consultation hospital or this admission and 4370 (63.9%) underwent PCI during this hospitalization. Of these patients undergoing PCI, 3077 (70.4%) received PCI within 2 hours of admission and 3832 (87.7%) received stent implantation. The proportion of drug eluting stents, bare metal stents and others was 98.4%, 0.8% and 0.8%, respectively. Early dual antiplatelet therapy was given in 6302 (93.1%) patients without contraindications of aspirin and P2Y 12 inhibitors. The rates of early use of aspirin plus clopidogrel was 79.7% and aspirin plus ticagrelor was 21.2%, respectively (there were some patients receiving both clopidogrel and ticagrelor). In addition, glycoprotein IIb/IIIa receptor antagonist was given to 28.1% and anticoagulants to 75.8% of these patients during hospitalization. Of these receiving anticoagulants, 5.3% received unfractionated heparin, 90.5% low-molecular heparin, 3.5% fondaparinux sodium and 0.7% others. CONCLUSIONS For STEMI patients 75 years in China, there is still a gap in reperfusion therapy between the guideline recommendation and the clinical practice, especially for thrombolysis therapy. Although the use of early dual antiplatelet therapy is relatively high, additional opportunities to improve care exist. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 72, NO. 16, SUPPL C, 2018 C107