Applied Mathematical Sciences, Vol. 8, 2014, no. 68, 3359 - 3374 HIKARI Ltd, www.m-hikari.com http://dx.doi.org/10.12988/ams.2014.44277 Application of Generalized Estimating Equation (GEE) Model on Students’ Academic Performance Isaac Owusu-Darko Mathematics Department Valley View University, Techiman, P. O. Box 183, Techiman Ghana, W/A Isaac Kwasi Adu Mathematics Department Valley View University, Techiman P. O. Box 183, Techiman, Ghana, W/A Nana Kena Frempong Mathematics Department Kwame Nkrumah University of Science and Technology Ghana, West Africa Copyright © 2014 Isaac Owusu-Darko, Isaac Kwasi Adu and Nana Kena Frempong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract This paper illustrates analysis of longitudinal data on students’ academic performance using GEE (Generalize Estimation Equations) under various working correlation assumptions. Many factors account for students’ academic performance in the fulcrum of all levels of education. Hence, any variable that triggers the academic performance of students evoke the awareness of all. The aim of this thesis is to analyze academic performance using application of Generalized Estimating Equation (GEE) Models under various working correlation assumptions. There are various statistical and mathematical models employed in the analyses of students’ academic performance in different level of schools. In this paper, we formulate the Generalized Estimating Equation (GEE) model approach under various correlation assumptions to analyze the probable