International Journal of Research in Medical Sciences | March 2023 | Vol 11 | Issue 3 Page 746 International Journal of Research in Medical Sciences Islam AM et al. Int J Res Med Sci. 2023 Mar;11(3):746-750 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Urothelial carcinoma of urinary bladder with histologic grading: a study in a tertiary care hospital, Bangladesh M. Ariful Islam 1 *, Ratim Mir 2 , Mohammed S. Ali Jinnah 1 , Rumana A. Sweety 1 , M. M. Rahman 1 INTRODUCTION Urinary bladder cancer is the 10th most common form of all cancers in this world. It is the sixth most common cancer and ninth leading cause of cancer death among men. 1 Urinary bladder cancer is more common in men than in women with a ratio of 3:1 globally. 2 The incidence and mortality rates were 9.6 and 3.2 per 100,000 in men and women respectively in 2018. The incidence of bladder cancer in Bangladesh was 1626 (1.1%), death was 992 (0.97%) and the 5-year prevalence rate was 2.08 in 2018 per 1,00,000 of population. 3 The rate of incidence of urinary bladder cancer is increasing with age. The highest incidence occurs in the 6 th and 7 th decades of life. 4 Though the incidence and prevalence were more in developed countries, the incidence is also increasing in developing countries like Bangladesh due to urbanization, increased use of chemicals and increased tobacco consumption. 1 Most of the cases (about 90%) of urinary bladder tumors are of epithelial origin, the remainder are of mesenchymal tumors. Most epithelial tumors are urothelial or transitional cell type. 5 The WHO classification of urothelial tumors is papilloma, papillary urothelial neoplasm of low malignant potential (PUNLMP), low grade urothelial carcinoma and high- grade urothelial carcinoma. 5,6 The aim and objectives of 1 Department of Pathology, Dhaka Medical College, Dhaka, Bangladesh 2 Department of Pathology, Sir Salimullah Medical College, Dhaka, Bangladesh Received: 30 October 2022 Accepted: 20 December 2022 *Correspondence: Dr. M. Ariful Islam, E-mail: maislam870@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Urinary bladder cancer is one of the most common forms of all cancers in the world. It is the ninth leading cause of death from cancer among men. The incidence of urinary bladder cancer in Bangladesh is increasing day by day. The aim of the study was to evaluate different clinic-pathological parameters of urothelial carcinoma of urinary bladder with the grade of the tumor. Methods: This study was a cross sectional study done over a period of two years, from March 2018 to February 2020 at the department of pathology, Dhaka medical college, Dhaka. Total 73 samples were collected, fixed overnight in 10% buffered formalin and stained with hematoxylin and eosin staining. Pathological grading was confirmed and different clinic-pathological parameters were evaluated. Results: Most of the cases (22 cases, 30.1%) were found in the fifth decade (51-60). Mean age of the patients was found to be 60.85 (±12.72) years, 58 (79.5%) cases were male and 15 (20.5%) cases were female with male to female ratio of 3.9:1. Most of the cases (49 cases, 67.1%) were smokers. Most common clinical presentation was hematuria (91.8% cases), most frequent tumor location was the lateral wall of the urinary bladder and 75.3% cases were reported as high-grade urothelial carcinoma. Conclusions: Different clinic-pathological parameters with histologic grading were evaluated in this study which may have a significant impact in epidemiology, diagnosis and assessment of biological behavior of urothelial carcinoma. Keywords: Urothelial carcinoma, Gender, Age, Tumor grade, Location DOI: https://dx.doi.org/10.18203/2320-6012.ijrms20230294