International Journal for Multidisciplinary Research (IJFMR) E-ISSN: 2582-2160 ● Website: www.ijfmr.com ● Email: editor@ijfmr.com IJFMR23045775 Volume 5, Issue 4, July-August 2023 1 Biosensors in Detection of Nickel Hypersensitivity Rochana Mahesh 1 , Suma S. 2 , Pradeep S 3 1 PG Student, Department of Orthodontics, JSS Dental College and Hospital 2 Reader, Department of Orthodontics, JSS Dental College and Hospital 3 Lecturer, Department of Orthodontics, JSS Dental College and Hospital ABSTRACT Usage of numerous dental materials, starting from diagnosis to rehabilitation for the management of oral diseases are not devoid of posing a potential risk of inducing allergic reactions to the patient, technician and dentist. The materials used for dental restorations, orthodontic instruments etc must satisfy the biocompatibility specifications since they are indicated for a long time in the oral cavity.Popular usage of nickel in dentistry has brought about an unpopular trend in allergic reactions. The wave of metal allergies that are the result of nickel usage in orthodontics, are more prevalent in dentistryMetallic taste, angular cheilitis, and periodontitis may be associated with release of nickel from orthodontic appliances. It is manifested as Nickel Allergic Contact Stomatitis (NiACS). A burning sensation is the most frequent symptomA systematic approach for the selection and monitoring of dental materials used in orthodontics thereby giving an insight to predict their risk of inducing allergic reactions. The scope of detection of dental materials related allergies can be used chairside before introducing the material to the oral cavity. Use of detection may not be used only for diagnostic method but also a therapeutic method. Hence, dental materials related allergen detection, and management have become significant priorities within the healthcare fraternity, and there is an urgent requirement for reliable, sensitive, and user-friendly technologies to trace allergens in dental materials. KEYWORDS:Nickel hypersensitivity, Contact dermatitis, Biosensor, Patch test INTRODUCTION Nickel allergy is a type of contact dermatitis caused by direct contact with nickel. It is the most common cause of metal-related contact dermatitis and may be seen in healthcare. In orthodontic treatments we use brackets, bands, wires etc. which contain nickel 8%. Absorption of Nickel into the system is quick, and it causes delayed hypersensitivity reaction. Nickel Allergic Contact Stomatitis (NiACS) a burning sensation is the most frequent symptom. Metallic taste, angular cheilitis, and periodontitis may be associated with release of nickel from orthodontic appliances. Patch testing represents the gold standard for the diagnosis of ACD from nickel. METAL ALLERGY Metals are pervasive in our environment and are frequently utilized in costume jewelry, coins, mobile phones, and dental materials. These metals include gold (Au), silver (Ag), mercury (Hg), nickel (Ni), titanium (Ti), chromium (Cr), copper (Cu), and cobalt (Co). Contact hypersensitivity to metals affects roughly 10%–15% of the population of humans. [1,2] With an estimated population frequency of 10% in