Accepted Manuscript Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties Nesrin Buğday, F. Zehra Kü ç ükbay, Hasan Kü ç ükbay, Silvia Bua, Gianluca Bartolucci, Janis Leitans, Andris Kazaks, Kaspars Tars, Claudiu T. Supuran PII: S0045-2068(18)30774-0 DOI: https://doi.org/10.1016/j.bioorg.2018.08.032 Reference: YBIOO 2489 To appear in: Bioorganic Chemistry Received Date: 27 July 2018 Revised Date: 14 August 2018 Accepted Date: 26 August 2018 Please cite this article as: N. Buğday, F. Zehra Kü ç ükbay, H. Kü ç ükbay, S. Bua, G. Bartolucci, J. Leitans, A. Kazaks, K. Tars, C.T. Supuran, Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties, Bioorganic Chemistry (2018), doi: https://doi.org/10.1016/j.bioorg. 2018.08.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.