International Journal of Medical Nano Research Rafati et al. Int J Med Nano Res 2020, 7:031 Volume 7 | Issue 1 Open Access ISSN: 2378-3664 DOI: 10.23937/2378-3664.1410031 Citaton: Rafat A, Zarrabi A, Gill P (2020) Origami-Induced Alignment of MNP Inside of DNA Nano- tubes. Int J Med Nano Res 7:031. doi.org/10.23937/2378-3664/1410031 Accepted: February 18, 2020: Published: February 20, 2020 Copyright: © 2020 Rafat A, et al. This is an open-access artcle distributed under the terms of the Creatve Commons Atributon License, which permits unrestricted use, distributon, and reproducton in any medium, provided the original author and source are credited. • Page 1 of 7 • Rafati et al. Int J Med Nano Res 2020, 7:031 Origami-Induced Alignment of MNP Inside of DNA Nanotubes Adele Rafat 1,2* , Ali Zarrabi 3 and Pooria Gill 1,4 1 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran 2 Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran 3 Nanotechnology Research and Applicaton Center, Sabanci University, Sabanci, Turkey 4 Nanomedicine Group, Immunogenetcs Research Center, Mazandaran University of Medical Sciences, Sari, Iran *Corresponding author: Adele Rafat, Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran Abstract Background: The advent of nanotubes in the nanotechnol- ogy world has led to signifcant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and poten- tial to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis control- lability and programmability in shape/size/length/diameter and its biological origin compared to different types of nano- material, can be the suitable candidate for template pattern- ing alignment and precise organization of nanoparticles at surface or into channel. These characteristics can be used in nanoelectronic devise or in the feld of diagnostic nano- biosensores. Methods: Here, we report a new construction methodolo- gy for encapsulation of magnetic nanoparticles inside DNA nanotubes channel. Constructed-simultaneously encapsu- lation of magnetic nanoparticles into the large channel of this tubes leads to “pea-pod” particle alignment in nanotube channel. Results: Transmission electron microscopy and atomic force microscopy confrmed the fabrication of DNA nanotubes con- tained the magnetic nanoparticles inside the channel. Conclusion: These biohybrid nanomaterial would be pro- posed as the nanoarray platform in nanobiosensing devices. Keywords DNA nanotubes, Magnetic nanoparticles, Transmission elec- tron microscopy, Atomic force microscopy, Nanobiosensors Introducton Deoxyribonucleic acid (DNA) has recently suggest- ed opportunites for the fabricatons of nanostructures and massively constructon of the artfcial nanoarchi- tectures with various geometries or paterns by the self-assembly phenomena [1-6]. Scafolded DNA ori- gami has become a unique technique for designing well-defned nanostructures with any desired shape and patern because of programmability and controlla- bility in fabricaton and for the controlled arrangement of functonal nanostructures with few nanometer res- olutons [7,8]. DNA nanotechnology also has used DNA strands to assemble gold, Magnetc and other nanopar- tcles into distnct 1, 2-D structures, or into periodic 3-D crystals [9,10]. Combining the novel electronic, magnetc, and optcal propertes of either semicon- ductor or metallic nanopartcles with the self-assem- bly propertes of DNA strands can led to constructon of new hybrid bio-nanomaterial with ability to precise organizaton and alignment of nanopartcles [11,12]. These unique features make DNA origami nanostruc- tures appropriate candidates for use as platorm to alignment of nanopartcles for nanodevices fabrica- ton. Consequently, a number of studies have shown the precise organizaton of metallic nanopartcles on/ in various DNA origami shapes [13,14]. Among the various types of DNA nanostructures, DNA nanotubes, due to their unique characteristcs, such as surface-to-volume rato, controllability and pro- OriGinAl Article Check for updates