_____________________________________________________________________________________________________ *Corresponding author: E-mail: sadri@unizwa.edu.om, sadrinofli@gmail.com; British Journal of Pharmaceutical Research 15(5): 1-8, 2017; Article no.BJPR.32459 ISSN: 2231-2919, NLM ID: 101631759 SCIENCEDOMAIN international www.sciencedomain.org In vitro Anticancer Activity of Selected Medicinal Plants from Oman Sadri Abdullah Said 1* , Yahya Tamimi 2 , Md. Sohail Akhtar 1 , Afaf Mohd Weli 1 , Suleiman Said Al-Khanjari 3 and Qassim Ahmed Al-Riyami 1 1 School of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Oman. 2 Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Oman. 3 DARIS Research Center, University of Nizwa, Oman. Authors’ contributions This work was carried out in collaboration between all authors. Author SAS designed the study, wrote the protocols, performed laboratory and statistical analyses and wrote the first draft of the manuscript. Author YT wrote the protocol, performed statistical analysis and managed cytotoxic analysis. Authors MSA and AMW designed the study, collected the plant materials and managed laboratory analysis. Authors SSAK and QAAR designed the study. All authors read and approved the final manuscript. Article Information DOI: 10.9734/BJPR/2017/32459 Editor(s): (1) Cheng Wang, Division of Neurotoxicology, National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), USA. Reviewers: (1) Lorna T. Enerva, Polytechnic University of the Philippines, Philippines. (2) Özlem Sultan Aslantürk, Adnan Menderes University, Turkey. (3) F .O. Osunsanmi, University of Zululand, South Africa. Complete Peer review History: http://www.sciencedomain.org/review-history/18639 Received 27 th February 2017 Accepted 10 th April 2017 Published 14 th April 2017 ABSTRACT This paper reports in vitro anticancer activity of hexane, chloroform, ethyl acetate, butanol and water extracts obtained from twelve (12) medicinal plants including Aloe dhufarensis, Calotropis procera, Juniperus servaschanica, Lawsonia inermis, Maytenus dhofarensis, Moringa peregrina, Polygala senensis, Punica granatum, Rhazya stricta, Solanum incanum, Teucrium mascatense. and Zataria multiflora collected from Oman. Crude ethanol extracts prepared by maceration of plant materials in ethanol were Kupchan partitioned to give hexane, chloroform, ethyl acetate, butanol and aqueous fractions. Cytotoxicities of the prepared fractions were measured by Alamar blue assay against ovarian cancer cell line (MCAS) and breast cancer cell line (MDA MB231). Thirteen extracts from five plants C. procera, J. servaschanica, M. dhofarensis, S. incanum and Original Research Article