Please cite this article as: Panigrahi G et al., Investigation of Antidiarrhoeal and Antimotility Activities of Methanolic Extract of Musa Sapientum Flowers and Fruit Peels. American Journal of Pharmacy & Health Research 2018. Research Article www.ajphr.com 2018, Volume 6, Issue 08 ISSN: 2321–3647(online) Investigation of Antidiarrhoeal and Antimotility Activities of Methanolic Extract of Musa Sapientum Flowers and Fruit Peels Gourahari Panda, P. Narasimha Murthy, Iswori Prasad Padhy, Ghanshyam Panigrahi* Department of Pharmacognosy, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur, Odisha, India, Pin -760002. ABSTRACT The objective of the present study was investigation of antidiarrhoeal and antimotility activities of methanolic extract of musa sapientum (family- Musaceae) flowers and fruit peels. The phytochemical analysis of both extracts of Musa sapientum revealed the presence of alkaloids, carbohydrates, glycosides, saponins, proteins, coumarins, flavonoids, triterpenoids, tannins and phenolic compounds. The extracts were evaluated for castor oil- induced diarrhoea and intestinal motility test in rats. Both the methanolic extracts were significantly (p<0.05) and dose dependently reduced frequency of stooling in castor oil-induced diarrhoea and anti-motility action in intestinal motility test. These findings suggest that the methanolic extract of the musa sapientum flowers and fruit peels may contain some biologically active ingredients that are useful for the treatment of diarrhoea. Key words: Musa sapientum, Antidiarrhoeal, castor oil, antimotility, phytochemical *Corresponding Author Email: pvprofvenkat51@gmail.com Received 10 July 2018, Accepted 22 July 2018