264 Pak J Med Sci 2013 Vol. 29 No. 1 Special Supplement IUMS www.pjms.com.pk Open Access INTRODUCTION Obesity plays a crucial rule in the development of the most common risk factors for diabetes, hypertension, atherosclerosis and metabolic syndrome (MetS). 1,2 MetS can easily be diagnosed by using clinical settings and threshold values for abdominal obesity, hypertension, high fasting Correspondence: Dr. Masoumeh Sadeghi, Associate Professor in Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: sadeghimasoumeh@gmail.com Original Article Correlation of circulating infammatory markers, ghrelin, adiponectin with obesity indices in subjects with metabolic syndrome Mojgan Gharipour 1 , Masoumeh Sadeghi 2 , Marjan Mansourian 3 , Elham Andalib 4 , Mohammad Talaie 5 , Noushin Mohamadifard 6 , Nizal Sarrafzadegan 7 ABSTRACT Objective: The goal of this study was to evaluate the association of obesity indices with circulating infammatory markers in subjects diagnosed Metabolic Syndrome (MetS). Methodology: Random selection of individuals’ samples from participants of Isfahan Cohort Study (ICS) was used. Only subjects who met the National Cholesterol Education Program’s Adult Treatment Panel III (ATP-III) criteria were included in the study. All participants underwent a 30-minute face to face interview to complete validated questionnaires. A trained nurse measured obesity indices such as body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and waist to height ratio (WHtR). Serum total cholesterol, triglycerides, HDL, LDL, fasting blood glucose, interleukin-6 (IL-6), interleukin-10 (IL-10), adiponectin, ghrelin and CRP were also measured. The Mann- Whitney U test was used to compare the infammatory markers in subjects with and without MetS. Correlation coeffcients between infammatory biomarkers and obesity indices were evaluated in participants with MetS using Pearson Coeffcient correlation test. Results: In subjects with MetS, WC and BMI were signifcantly higher compared to subjects without MetS (P < 0.001). We found the median Interquartile range (IQR) of CRP was signifcantly higher in subjects with MetS (P < 0.001). Adiponectin and ghrelin level showed no signifcant difference in subjects with or without MetS. Subjects with MetS had a statistically signifcant positive correlation between IL6 and WHtR (r =0.367, P = 0.015). No signifcant correlation was found between IL-10, ghrelin, adiponectin and CRP with BMI, WHtR and WC. Negative correlation was observed for adiponectin and the WC (r = -0.367, P = 0.026) as well. Conclusion: Our fndings indicate that in subjects diagnosed with MetS, only IL6 had positive association with WHR and no signifcant correlation between all other infammatory markers with Obesity Indices was found. KEY WORDS: Infammatory markers, Obesity, Metabolic syndrome. doi: http://dx.doi.org/10.12669/pjms.291(Suppl).3513 How to cite this: Gharipour M, Sadeghi M, Mansourian M, Andalib E, Talaie M, Mohamadifard N, et al. Correlation of circulating infammatory markers, ghrelin, adiponectin with obesity indices in subjects with metabolic syndrome. Pak J Med Sci 2013;29(1)Suppl:264-268 doi: http://dx.doi.org/10.12669/pjms.291(Suppl).3513 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.