Фітотерапія. Часопис № 1, 2023 37 Медицина © S. Parchami, T. Harnyk, E. Gorova, P. Sereda, K. Marchenko-Tolsta, M. Hameed UDC 615.322.6157.014 Sepideh PARCHAMI GHAZAEE candidate of Biological Sciences, Assistant, Assistant of the Department of Pharmacology, clinical Pharmacology, Pathological Physiology, Kyiv Medical University, Boryspilska str., 2, Kyiv, Ukraine, 02099 (Sep_par_71@ukr.net) ORCID: 0000-0002-3829-3270 Tetyana HARNYK Doctor of Medical Sciences, Professor, Professor of the Department of Physical Education, Sports and human health, Vernadsky Taurida National University, John Mc cain str., 33, Kyiv, Ukraine, 01042 (phitotherapy.chasopys@gmail.com) ОRCID: 0000-0002-5280-0363 Ella GOROVA candidate of Medical Sciences, Associate Professor, Associate Professor of the Department of Physical Education, Sports and health, Vernadsky Taurida National University, John Mc cain str., 33, Kyiv, Ukraine, 01042 (gorova.ella@tnu.edu.ua) ORCID: 0000-0003-0259-5469 Petro SEREDA Doctor of Medical Sciences, Professor, head of the Department of Pharmacology, clinical Pharmacology, Pathological Physiology, Kyiv Medical University, Boryspilska str., 2, Kyiv, Ukraine, 02099 (p.sereda@kmu.edu.ua) ORCID: 0009-0005-6005-9615 Kateryna MARCHENKO-TOLSTA Senior Lecturer, Senior Lecturer of the Department of Pharmacology, clinical Pharmacology, Pathological Physiology, Kyiv Medical University, Boryspilska str., 2, Kyiv, Ukraine, 02099 (k.marchenko-tolsta@kmu.edu.ua) ORCID: 0000-0001-7744-5874 Murtaza HAMEED 5th year Student of Medicine, Department of Pharmacology, clinical Pharmacology, Pathological Physiology, Kyiv Medical University, Boryspilska str., 2, Kyiv, Ukraine, 02099 (m.hameed.st@kmu.edu.ua) ORCID: 0000-0003-0570-1108 DOI 10.32782/2522-9680-2023-1-37 To cite this article: Parchami Ghazaee S., Harnyk T., Gorova E., Sereda P., Marchenko-Tolsta K., Hameed M. (2023). Rol ftozasobiv u terapii revmatoidnoho artrytu (Ohliadova stattia) [Role of phytochemicals treatments in managing rheumatoid arthritis (review article)]. Fitoterapiia. chasopys – Phytotherapy. Journal, 1, 37–43, doi: 10.32782/2522-9680-2023-1-37 ROLE OF PHYTOCHEMICALS TREATMENTS IN MANAGING RHEUMATOID ARTHRITIS (REVIEW ARTICLE) Non-steroidal anti-infammatory drugs are one of the symptomatic treatment options for rheumatoid arthritis (RA). However, these medications are known to have multiple adverse efects. Although biological medications target molecular pathways involved in the infammatory process of RA, there is a lack of long-term safety data. This review aims to present the novel insights of recent studies investigating medicinal plants, phytochemicals and their pharmacological activities against RA. Punicalagin reduces release of LPS-induced nitric oxide, TNF-α, and IL-6 by suppressing NF-κB and MAPK signaling pathways that are responsible for apoptosis of chondrocytes. Anthocyanins decrease the number of Th17 cells and suppress Th17 cells diferentiation in vivo and in vitro. Also, anthocyanins inhibit osteoclasts via downregulation of cytokines including IL-1, IL-6, IL-17, and TNF-α in vitro. Oral ellagic acid in arthritic rats considerably decreases paw edema and levels of chitinase-3-like protein-1, which is induced via the NF-κB pathway and overexpression of which is associated with the infammatory process of RA in chondrocytes and synovial tissue. Punicic acid reduces MMP9 gene expression, associated with the activation of NF-κB, which may mediate its anti-infammatory efect in osteoarthritis. Although to date natural products are mainly used as nutraceuticals, the treatment of RA by medicinal plants needs more investigation to fully explore their potential as pharmacological agents in the treatment of autoimmune infammatory diseases. Key words: rheumatoid arthritis, punicalagin, anthocyanins, ellagic acid, punicic acid, anti-infammatory phytochemicals.