PENELITIAN Profil Klinikopatologik Keganasan Ampula Vateri dan Pankreas P-ISSN 0215-7284 Meike Pramono dkk e-ISSN 25279106 Terakreditasi KEMENRISTEKDIKTI/Sinta-3 633 Maj Patol Indones 2023; 32(2): 633-639 DOI: 10.5586/mpi.v32i2.621 Profil Klinikopatologik Keganasan Ampula Vateri dan Pankreas di RSUP Nasional Dr. Cipto Mangunkusumo Tahun 2015-2019 Meike Pramono, Diah Rini Handjari Departemen Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Jakarta Penulis korespondensi: Dr. dr. Diah Rini Handjari, SpPA(K). Departemen Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia Jl. Salemba Raya No. 6, Jakarta e-mail: rinidiah@gmail.com: meikepramono@gmail.com ABSTRAK Latar belakang Keganasan pankreas dan keganasan ampula vateri sering sulit dibedakan. Keganasan di ampula vateri meliputi keganasan pada papilla duodenalis mayor, distal duktus biliaris komunis dan muara duktus pankreatikus (Wirsung). Asal tumor primer, diagnosis histopatologi dan staging berperan dalam terapi dan prognosis. WHO Classification of tumours of the digestive system 2019 melakukan perubahan staging tumor mengikuti sistem dari the American Joint Committee on Cancer (AJCC), edisi 8. Studi ini dilakukan untuk mengetahui jenis-jenis keganasan pankreas dan ampula vateri, sebaran demografik, lokasi, profil histomorfologi serta perubahan staging tumor pada AJCC edisi 7 menjadi AJCC edisi 8 pada WHO Classification of tumours of the digestive system, 2019. Tujuan penelitian ini untuk mengetahui profil klinikopatologik keganasan pankreas dan ampula vateri serta perubahan staging tumor berdasarkan AJCC edisi 8. Metode Penelitian deskriptif observasional pada sediaan reseksi keganasan pankreas dan ampula vateri di Departemen Patologi Anatomik FKUI/RSCM, periode Januari 2015 sampai Desember 2019 yang memenuhi kriteria inklusi. Dilakukan evaluasi demografik, lokasi tumor, profil histopatologik dan perubahan staging pasien berdasarkan AJCC edisi 8. Hasil Terdapat 27 kasus adenokarsinoma di ampula vateri, 10 kasus adenokarsinoma duktal pankreas, 1 kasus mucinous cystic neoplasm dengan fokus adenokarsinoma, 1 kasus serous cystadenocarcinoma, 7 kasus PanNET, 2 kasus PanNEC, 3 kasus SPN, 1 kasus MiNEN. Perubahan pT terdapat pada 29 kasus. Perubahan pN terdapat pada 6 kasus. Kesimpulan Penegakan diagnosis dan staging patologi sesuai WHO Classification of tumours of the digestive system, 2019 Diferensiasi tumor, ada tidaknya invasi limfovaskular, invasi perineural dan metastasis ke kelenjar getah bening serta status batas sayatan merupakan parameter histopatologi yang perlu diperhatikan. Kata kunci: keganasan ampula vateri, keganasan duktal pankreas Clinicopathological Profile of Ampulla of Vater and Pancreas Malignancies at Cipto Mangunkusumo Hospital in 2015-2019 ABSTRACT Background Malignancies of ampulla of vater and pancreas are often difficult to distinguish. Malignancies in ampulla of vater include malignancies in major duodenal papilla, distal common bile duct and pancreatic duct opening (Wirsung). The origin of the primary tumor, histopathological diagnosis and staging play a role in therapy and prognosis. WHO Classification of tumors of the digestive system, 2019 made changes in tumor staging following the system of the American Joint Committee on Cancer (AJCC), 8 th edition. This study was conducted to determine types of pancreatic and ampullary malignancies, demographic distribution, location, profile, histomorphology and tumor staging changes in the 7 th edition of the AJCC to 8 th edition of the AJCC in the WHO Classification of tumors of the digestive system, 2019. The aim to determine clinicopathological profile of malignancies of ampulla of vater and pancreas as well as tumor staging changes based on AJCC edition 8. Methods Observational descriptive study on pancreatic and ampulla vater malignancy resection preparations at Department of Anatomic Pathology FKUI/RSCM, period January 2015 to December 2019 that met the inclusion criteria. Demographic evaluation, tumor location, histopathological profile and patient staging changes were carried out based on the 8 th edition of AJCC. Results There were 27 cases of adenocarcinoma in ampulla of vater, 10 cases of pancreatic ductal adenocarcinoma, 1 case of mucinous cystic neoplasm with adenocarcinoma focus, 1 case of serous cystadenocarcinoma, 7 cases of PanNET, 2 cases of PanNEC, 3 cases of SPN, 1 case of MiNEN. Changes in pT were present in 29 cases. Changes in pN were present in 6 cases. Conclusion The diagnosis and pathological staging are in accordance with the 2019 WHO digestive system tumor classification. Tumor differentiation, presence or absence of lymphovascular invasion, perineural invasion and lymph node metastases and incision margin status are important histopathological parameters. Keywords: ampullary adenocarcinoma, pancreatic ductal adenocarcinoma. Received : 30-03-2022 Accepted : 10-05-2022 Published : 22-05-2023