How to Cite: El-Ghany, A. A. A., Elsayed, H. M., Goda, A. A., Abogabal, A. D., Sadek, G. E. M., & Dewedar, K. S. A. (2021). Effect of two desensitizing agents on post-operative hypersensitivity of composite resin restorations. International Journal of Health Sciences, 5(S1), 763–769. https://doi.org/10.53730/ijhs.v5nS1.14297 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2021. Manuscript submitted: 4 Jan 2021, Manuscript revised: 25 Jan 2021, Accepted for publication: 21 Feb 2021 763 Effect of two desensitizing agents on post- operative hypersensitivity of composite resin restorations Ahmed Ata Abd El-Ghany Assistant Professor of Operative Dentistry Al-Azhar University (Assiut branch), Egypt Email: dr.ahmadata@yahoo.com Hosam Muhammed Elsayed Lecturer of Dental Biomaterial Department -Alazhar university, Assiut branch, Egypt Email: Hossamahmed.46@azhar.edu.eg Ahmed Ali Goda Lecturer, Department of operative dentistry Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt Email: Ahmed.goda.82@azhar.edu.eg Ahmed Dahy Abogabal Department of Dental Biomaterials, Faculty of Dental Medicine (Boys), Assuit, Al- Azhar University, Egypt Email: ahmeddahy.4419@azhar.edu.eg Galal Eldeen Mosaad Sadek Lecturer in Dental biomaterials, Fuclty of Dentistry, Al-Azhar University, Egypt Email: galalsadek@hotmail.com Karim Sherif Adly Dewedar Lecturer of Crown and Bridge Al-Azhar University Cairo-Boys Email: Karimadly.209@azhar.edu.eg Abstract---Post-operative hypersensitivity still occurs although the improvements in adhesive systems and their techniques, so the current study was conducted to evaluate the efficacy of two desensitizing systems. Materials and methods: A total No. of 48 patients were randomly divided into 3 groups (n=16); Gluma group, SAD group, and control group. Class I cavity preparation and self-etch bonding technique was used by Universal bonding system in the control group, before that desensitizing agent was applied in the two