Conclusion: The data indicate nearly 1/3rd of population are at risk. The urban population is at higher risk than rural ( p < 0.001). This data has social relevalence for strategic planning at population level to prevent ACS. Results of a comprehensive coronary heart disease prevention program in South India N. Sakthi Vinayagam, N. Ezhil Vani, V. Chockalingam, Priya Chockalingam * Cardiac Wellness Institute, Chennai, India Objective: Coronary heart disease (CHD) is a major cause for mortality and morbidity among Indians. However, the focus on lifestyle measures in the prevention of CHD in the country is abysmally low. We aimed to analyse the outcomes of a compre- hensive CHD prevention/rehabilitation program in South India. Methods: All patients enrolled between May 2014 and April 2015 with established CHD (n = 32) or with documented risk-factors and no CHD (n = 28) were included in the study. Patients attended 1–2 ses- sions per week for 6–12 weeks. Each session lasted 90–100 min and included an exercise component and an education/counselling com- ponent on diet, activity, compliance to therapy, risk-factor modifica- tion and psychosocial aspects. Apart from clinical and family history, resting heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), waist–hip ratio and functional capacity using treadmill test (TMT) or 6 min walk test (6MWT) were documented before (pre) and after (post) the program. Adherence was considered good if a patient attended >50% of the sessions enrolled and poor if ≤50%. Fischer's exact test and student's t-test were used to compare categorical and continuous variables respectively; p value < 0.05 was considered statistically significant. Results: Subjects with CHD were older (61 Æ 10 years vs 50 Æ 15 years, p = 0.002), predominantly males (84% vs 57%, p = 0.02), showed better adherence (84% vs 61%, p = 0.046) and attended more sessions (11.1 Æ 6.4 vs 6.9 Æ 3.6, p = 0.03) than non-CHD subjects. In the CHD group, medical therapy was documented in all (100%), CABG in 4 (12%), PTCA in 3 (9%) and heart failure in 5 (16%) subjects. Among all (n = 60) enrolled subjects, 37 (62%) completed their program and 23 (38%) could not complete due to various reasons. Post-program evaluation showed significant improvement in cardiac symptoms, BMI, SBP and functional capacity (Table 1). The 6MWT seems to be an efficient and reliable tool for functional capacity assessment in our setting. Conclusion: Cardiac rehabilitation, a key component in the man- agement of CHD, is under-utilised in India. This study shows that an exercise-cum-education program has significant benefits in a South Indian cohort and can potentially be incorporated in the routine management of all patients with (risk of) CHD. Burden of cardiovascular risk in young, apparently healthy individuals in the Indian sub-continent: Time for intervention? R. Narain, S. Sharma Department of Cardiovascular Sciences, St George's University of London, United Kingdom Purpose: The majority of sudden cardiac deaths (SCD) are attributed to atherosclerosis and affect the older section of the population. Ischaemic heart disease in India accounts for 61,000,000 deaths per year, despite the youth of its population, with 65% of individuals aged <35 years. Although a high prevalence of cardiovascular risk factors in the young appears the most plausible explanation, there are no supporting data. The study aimed to define the prevalence of cardiovascular risk factors & quiescent heart disease in a cohort of young, apparently healthy Indians. Methods: A cohort of 751 consecutive individuals (69% male) with a mean age 21 years (range 15–40 years) underwent screening with a health questionnaire relating to cardiac symptoms, cardiovascular risk factors and family history of cardiovascular disease or pre- mature (<40 years) SCD and physical examination. All participants underwent a blood pressure (BP) measurement, capillary blood glucose, lipid profile analysis and 12-lead ECG. Individuals with ECG anomalies or a murmur underwent transthoracic echocardio- graphy on site. All participants received life style modification advice. Individuals with abnormal results were referred for further investigations as per local protocols. Results: During initial evaluation 63 (8.4%) individuals demon- strated a positive finding: 20 (2.7%) had elevated total cholesterol levels defined as >6 mmol/l, 13 (1.8%) had elevated BP defined as systolic BP >140 mmHg and 15 (2%) had elevated fasting glucose levels defined as >7 mmol/l. Echocardiography was performed on 15 (2%) individuals who exhibited a cardiac murmur or an abnormal ECG. Echocardiography revealed moderate mitral stenosis (n = 4), mild aortic stenosis (n = 3) and hypertrophic cardiomyopathy (n = 2). An additional 9 (1.2%) individuals were classed as obese (BMI > 30). On follow-up, all diagnoses were confirmed by respective physicians and individuals received treatment and follow-up as appropriate. Conclusion: Our results indicate a high burden of cardiovascular risk factors and quiescent heart disease in an unselected population of young Indians. This is in excess of what is reported in Caucasian populations and the most plausible explanation for the high cardi- ovascular morbidity and mortality in the Indian sub-continent. A large-scale population screening program is likely to identify a considerable proportion of young individuals at risk, however, its feasibility and cost-effectiveness remains to be defined. Study on clinical profile of metabolic syndrome in elderly and its relation with highly sensitive C-reactive protein (hs CRP) Ramakrishna Janapati, M. Jyotsna, Satyanarayana Raju Yadati * Department of Medicine, NIMS Hospital, Panjagutta, Hyderabad, Telangana, India Table 1 – Outcomes of the CHD prevention program. Characteristics Pre-program (n = 37) Post-program (n = 37) p Effort angina, n (%) 8 (22) 1 (3) 0.03 Heart rate (bpm) 77 Æ 11 75 Æ 14 0.44 SBP (mmHg) 135 Æ 16 127 Æ 13 0.03 DBP (mmHg) 78 Æ 10 81 Æ 9 0.16 BMI (kg/m 2 ) 27.2 Æ 5.8 26.9 Æ 5.7 0.01 WHR 0.99 Æ 0.05 0.98 Æ 0.04 0.79 Functional capacity a 6MWD (m, n = 29) 416 Æ 120 488 Æ 143 <0.001 TMT, METS (n = 6) 6.1 Æ 1.9 7.8 Æ 1.9 0.047 a Functional capacity could not be evaluated in 2 patients. 6MWD, 6 min walk distance; BMI, body mass index; DBP, diastolic blood pressure, METS, metabolic equivalents; SBP, systolic blood pressure; TMT, treadmill test; WHR, waist hip ratio. indian heart journal 67 (2015) s109–s116 S113 CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector