How to Cite: Farman, H. A., & Abuhinna, K. A. (2022). Evaluation of Endoglin (sEng)/CD105 level in women with polycystic ovary syndrome at Al-Najaf Province. International Journal of Health Sciences, 6(S1), 11488– 11493. https://doi.org/10.53730/ijhs.v6nS1.7786 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 March 2022, Manuscript revised: 9 April 2022, Accepted for publication: 18 May 2022 11488 Evaluation of Endoglin (sEng)/CD105 level in women with polycystic ovary syndrome at Al- Najaf Province Hassan Ali Farman Al-Furat AL-Awsat University Collage of health and medical technologies, Kufa Karrar Abed Abuhinna Al-Furat AL-Awsat University Collage of health and medical technologies, Kufa Abstract---Endoglin (sEng)/CD105 is a transmembrane auxiliary receptor for transforming growth factor beta (TGF-b) it works as a non-signaling coreceptor of the TGF-b modulating its responses. The main finding of these study that, in obese groups (PCOS and control), there were higher values of TGF-b1 and the lower values of plasma sEng. Even more importantly. Keywords---Endoglin (sEng)/CD105, polycystic ovary syndrome, women. Introduction Polycystic ovary syndrome (PCOS) is the most common gynecological disease in women at reproductive age, which is characterized by metabolic and endocrine abnormalities, as well as chronic inflammation )Seyyed Abootorabi et al., 2018). The most common risk factors for the progress of PCOS include family history of PCOS, fast food diet habits, lack of physical exercise, body mass index and waist circumference (Begum et al., 2017). Endoglin (CD105) is a 180-kDa homodimeric glycoprotein composed of two 95 kDa disulfide-linked subunits. It has a transmembrane structure and functions as a component of the transforming growth factor-β receptor complex. Endoglin is highly expressed on proliferating endothelial cells, A soluble form of endoglin (sEng) is found in the circulation under normal and pathologic conditions (Bock, et al,. 2011). Endoglin (sEng)/CD105 is a transmembrane auxiliary receptor for transforming growth factor beta (TGF-b) it works as a non-signaling coreceptor of the TGF-b modulating its responses. There are a number of reports suggesting that soluble endoglin may be regarded as a biomarker of endothelial dysfunction, for instance,