Posted on 2 Jun 2023 | The copyright holder is the author/funder. All rights reserved. No reuse without permission. | https://doi.org/10.22541/au.168570923.38034393/v1 | This a preprint and has not been peer reviewed. Data may be preliminary. An alternative treatment of diabetes with Ganoderma lucidum: a case report Khondaker Islam 1 , Masaud Hossain 2 , Bazlul Choudhury 3 , Nuhu Alam 4 , and Shahdat Hossain 4 1 Sher-e-Bangla Agricultural University 2 Shaheed Suhrwardi Medical college 3 Manikgonj Medical College 4 Jahangirnagar University June 2, 2023 Manuscript Type: Case Report —————————————————————————————————————————————————————————— - Title An alternative treatment of diabetes with Ganoderma lucidum : a case report a,d Khondaker Atiqul Islam, b Masud Hossain, c Bazlul Karim Choudhury, d Nuhu Alam, *, e, Shahdat Hossain id a Chief Farm Superintendent, Sher-E-Bangla Agricultural University, Dhaka, email: atiqul.sau@gmail.com b Oral & Maxillofacial Surgery, Shaheed Suhrwardi Medical college, Dhaka, Bangladesh; Email: masudhos- sain64@gmail.com c Dept. of Biochemistry, Manikgonj Medical College, Manikgonj, Dhaka, Bangladesh, email: bkc_ba- bor@yahoo.com d Department of Botany, Jahangirnagar University, Savar, Dhaka-1342; Email: mnabotju@yahoo.com Abstact Ganoderma lucidum is considered an effective medicinal mushroom. Therefore, it is interesting to investigate whether the beneficial effects of G. lucidum found in various in vitro or animal studies can be translated to chronic metabolic diseases such as diabetes in humans. Here, we present a case study of a diabetic patient who underwent treatment using G. lucidum in the form of a tea, and provide details on the patient’s fasting blood glucose (FG) level, lipid profile, and other blood parameters. After taking G. lucidum hot water extract, i.e. tea for three months, the FG values dropped from 198 mg/dl to 177.3 mg/dl. Total serum cholesterol decreased from 210 to 170 mg/dl and triglyceride level decreased from 220 to 150 mg/dl, while serum HDL-C increased from 25 to 35 mg/dl. LDL-C only dropped by 9 mg/dl. Serum creatinine, alkaline phosphatase (ALP), alanine aminotransferase, and total bilirubin levels were not altered. Therefore, it is concluded that G. lucidum hot water extract had antidiabetic and antidyslipidemic effects without affecting hepatorenal functions. 1