Evaluating Prophylactic And Therapeutic Efficacy Of Vanillic Acid On Neurodegenerative Disorders: A Narrative Review Section A-Research Paper Eur. Chem. Bull. 2023, 12(Regular Issue 1), 5115-5123 5115 EVALUATING PROPHYLACTIC AND THERAPEUTIC EFFICACY OF VANILLIC ACID ON NEURODEGENERATIVE DISORDERS: A NARRATIVE REVIEW Rasha M. Alderbi 1 , Mohammad Z. Alam 2 , Ulfat M. Omar 3 , Badrah S. Alghamdi 4 , Faisal S. Al-Shehri 5 , Maryam A. Al-Ghamdi 6* Abstract: Neurodegenerative illnesses, including Parkinson's disease (PD), Alzheimer's disease (AD), and ischemic stroke (IS), afflict a substantial portion of the global population. These illnesses exhibit a shared characteristic, namely neuroinflammation. Vanillic acid (VA), a phenolic acid found in various plant species, offers several health advantages, notably neuroprotection achieved via anti-inflammatory mechanisms. Therefore, the objective of this review is to compile and analyse various data pertaining to the preventative and therapeutic effects of VA on models of neuroinflammatory and neurodegenerative diseases. The evidence reported in this study elucidated the neuroprotective and therapeutic effects of VA in various animal models, hence substantiating the notion of VA's potential as a viable pharmaceutical candidate for the treatment of neurodegenerative illnesses. Keywords: Vanillic acid; Phenolic acid; Neurodegeneration; Neuroinflammation; Antioxidant; Anti- inflammatory; Alzheimer’s disease; Brain Ischemia 1,3,6* Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia 2,4 Preclinical Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia 2 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia 3,4 Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia 5 Medical Student, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 6* Vitamin D Pharmacogenomics Research Group, King Abdulaziz University, Saudi Arabia. 6* Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia *Corresponding Author: Maryam A. Al-Ghamdi Email: maaalghamdi3@ kau.edu.sa, Mobile no.: +966555683221 DOI: 10.48047/ecb/2023.12.1.566