International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR) | April 2021 | Volume 11 | Issue 2 | Page 24-30 Sowjanya Hatthi Belgal Mundarinti, Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature ISSN (Online) 2249-6084 (Print) 2250-1029 www.eijppr.com Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature Sowjanya Hatthi Belgal Mundarinti 1 , Hindustan Abdul Ahad 2 * 1 Department of Pharmaceutics, Research Scholar, JNTUA, Ananthapuramu-515001, Andhra Pradesh, India. 2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)- Autonomous, K. R. Palli Cross, Ananthapuramu-515721, Andhra Pradesh, India. ABSTRACT The main intention of floating microspheres is to elevate gastro-retentive time, there by drug release and bioavailability. Floating drug delivery systems glide on gastric fluid for an extended time without leaving the stomach and give good accessibility of the drug systemically and good duration of action for the prolonged period of time. Gastro-retentive microspheres are preferred for local action, local absorption, and preventing drug deterioration at the stomach. This article was made by pearly referring to published research papers of both online and offline journals on gastro retentive microspheres made by factorial design. The authors succeeded in collecting the information about the past decade of work done on gastro retentive drug delivery systems using factorial design. The authors from this study conclude that factorial design is an appreciable technique in the optimization of the gastro retentive dosage form in the form off microspheres for the drug delivery for the extended period of time. Key Words: Stomach, Target, Dosage form, Drug release. eIJPPR 2021; 11(2):24-30 HOW TO CITE THIS ARTICLE: Mundarinti S.H.B, Abdul Ahad H. Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature. . Int. J. Pharm. Phytopharmacol. Res. 2021;11(2):24-30. https://doi.org/ INTRODUCTION The oral route is harmless and real for decades for drug delivery [1, 2]. The drug liberates by this traditional oral route has fluctuation in the sum of medication reaching the blood with time as it has to pass different pH zones of the gut [3]. Novel approaches were made to solve this issue, among them gastro retentive systems gaining importance from researchers and formulation development scientists [4, 5]. Among the gastro, retentive systems microspheres are preferred for their ease in the making, flow properties (easy to fill in hard gelatin capsules). Floating drug delivery is intended to hold the drug in the stomach. Drugs with shorter half-lives that are readily absorbed in GIT are highly detached from the circulation of the serum [6, 7]. To resolve these difficulties, the oral managed drug delivery mechanism has risen as they liberate the drug into the GIT for longer periods and retain a steady concentration of medication in the serum. In the gastric area, the gastroprotective dosage type may last for few hours and thus significantly increase the drug GRT to improve bioavailability, minimize drug waste and improve the solubility of drugs with low solubility. Floating microspheres are empty spherical particles deprived of a centre, in a stringent sense with free-flowing particles [8] oscillating in size from 1 to 1000μm. Types of Gastro Retentive Dosage Forms Floating tablets These are low-density tablets which buoyant at the upper part of the stomach owing to their low density. These may be Effervescent floating tablets were made with swellable polymers and diverse effervescent compounds (combination of citric acid/tartaric acid with Sodium bicarbonate). When these tablets contact with the gastric Corresponding author: Hindustan Abdul Ahad Address: Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-515721, Andhra Pradesh, India. E-mail:  abdulhindustan @ gmail.com Received: 11 January 2021; Revised: 20 March 2021; Accepted: 29 March 2021