Please cite this article in press as: Aydo˘ gmus ¸ C ¸, et al. Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls? Allergol Immunopathol (Madr). 2017. http://dx.doi.org/10.1016/j.aller.2016.12.006 ARTICLE IN PRESS +Model ALLER-844; No. of Pages 4 Allergol Immunopathol (Madr). 2017;xxx(xx):xxx---xxx www.elsevier.es/ai Allergologia et immunopathologia Sociedad Espa ˜ nola de Inmunolog´ ıa Cl´ ınica, Alergolog´ ıa y Asma Pedi ´ atrica ORIGINAL ARTICLE Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls? C ¸. Aydo˘ gmus ¸ a , N.A. Ayaz b,* , M. C ¸akan b , F. C ¸ipe a , N. Topal c , Ö.B. Öner c , G. Keskindemirci c , A. Akc ¸ay d a Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Pediatric Allergy-Immunology Unit, Turkey b Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Pediatric Rheumatology Unit, Turkey c Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Pediatrics Unit, Turkey d Acıbadem University Medical Faculty, Pediatrics Unit, Turkey Received 23 October 2016; accepted 3 December 2016 KEYWORDS Familial Mediterranean fever; Atopy; Th1; Th2; Th17; Asthma; Allergy; Allergic rhinitis; Eczema Abstract Introduction: There are only a few studies regarding the prevalence of atopy in Familial Mediterranean fever (FMF) patients, and their results are conflicting. Methods: In this study children with the diagnosis of FMF were evaluated for the presence of atopy by comparing with controls. One hundred and eighteen children diagnosed as FMF and 50 healthy age and sex matched controls were enrolled. They were evaluated for the presence of rhinitis, atopic dermatitis, urticaria and asthma. Laboratory assessment was done by measuring IgA, IgM, IgG, IgE levels, total eosinophil count and by performing skin prick test (SPT) panels for common allergens to children with FMF and healthy controls. Results: One hundred and eighteen children (61girls and 57 boys) diagnosed as FMF with a median age of 120 ± 47 months (range 36---204 months) were compared with 50 healthy controls (31 girls and 19 boys) having a median age of 126 ± 37 (range 48---192 months). The mean per- centage of total eosinophil count of patients was similar to that of the control group. The mean level of IgE was significantly higher in children with FMF than controls (136 ± 268, 87 ± 201, respectively; p values <0.05). The percentage of skin prick test positivity was similar for both patients and controls (13% and 8.2%, respectively; p > 0.05). The prevalences of atopic der- matitis, allergic rhinitis, and asthma in the patient group were 5.08%, 28.8%, and 15.25%, respectively, while the control group had the prevalences of 0%, 36%, and 14% respectively. Conclusion: Children with FMF did not show an increase of atopic dermatitis, allergic rhinitis and asthma with respect to controls. © 2017 SEICAP. Published by Elsevier Espa˜ na, S.L.U. All rights reserved. ∗ Corresponding author. E-mail address: nurayaktay@gmail.com (N.A. Ayaz). http://dx.doi.org/10.1016/j.aller.2016.12.006 0301-0546/© 2017 SEICAP. Published by Elsevier Espa˜ na, S.L.U. All rights reserved.