Accepted Manuscript UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites Maria Francilene Souza Silva, Lorena Mara A. Silva, Amanda Lemos Quintela, André Gonzaga dos Santos, Francisca Aliny Nunes Silva, Fátima de Cássia E. de Oliveira, Elenilson Godoy Alves Filho, Edy Sousa de Brito, Kirley Marques Canuto, Claudia Pessoa, Guilherme Julião Zocolo PII: S1570-0232(18)31765-3 DOI: https://doi.org/10.1016/j.jchromb.2019.04.029 Reference: CHROMB 21609 To appear in: Journal of Chromatography B Received date: 17 December 2018 Revised date: 10 April 2019 Accepted date: 14 April 2019 Please cite this article as: M.F.S. Silva, L.M.A. Silva, A.L. Quintela, et al., UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites, Journal of Chromatography B, https://doi.org/10.1016/j.jchromb.2019.04.029 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.