514 Chapter XXVI Semantic Integration for Research Environments Tomasz Gubala University of Amsterdam, The Netherlands & ACC CYFRONET AGH, Poland Marian Bubak Institute of Computer Science AGH, Poland & University of Amsterdam, The Netherlands Peter M.A. Sloot University of Amsterdam, The Netherlands Copyright © 2009, IGI Global, distributing in print or electronic forms without written permission of IGI Global is prohibited. AbstrAct Research environments for modern, cross-disciplinary scientifc endeavors have to unite multiple us- ers, with varying levels of expertise and roles, along with multitudes of data sources and processing units. The high level of required integration contrasts with the loosely-coupled nature of environments which are appropriate for research. The problem is to support integration of dynamic service-based infrastructures with data sources, tools and users in a way that conserves ubiquity, extensibility and us- ability. This chapter presents a close examination of related achievements in the feld and the description of proposed approach. It shows that integration of loosely-coupled system components with formally- defned vocabularies may fulfll the listed requirements. The authors demonstrate that combining formal representations of domain knowledge with techniques like data integration, semantic annotations and shared vocabularies, enables the development of systems for modern e-Science. For demonstration they present how several semantically-augmented experiments are modeled in the ViroLab virtual laboratory for virology.