279 Incidence and risk factors of retinopathy of prematurity in the Lic. Adolfo López Mateos Regional Hospital, ISSSTE Incidencia y factores de riesgo de retinopatía del prematuro en el Hospital Regional Lic. Adolfo López Mateos, ISSSTE Dora A. Ochoa-Araujo 1 *, Vanesa Flores-Peredo 1 , Jessica T. Romero-Martínez 1 , Nancy L. Martínez-Rodríguez 2 and Oscar Medina-Contreras 3 * 1 Retina department, Hospital Regional Lic. Adolfo López Mateos, Instituto de Seguridad de Seguridad y Servicios Sociales de los Trabajadores del Estado; 2 Community Health Research Department, Hospital Infantil de México Federico Gómez; 3 Immunology and Proteomics Research Laboratory, Hospital Infantil de México Federico Gómez. Mexico City, Mexico ORIGINAL ARTICLE Abstract Objective: To determine the incidence of retinopathy of prematurity (ROP), and to analyze the main risk factors in premature new- borns of the Hospital Lic. Adolfo López Mateos. Methods: We performed a prospective study with preterm infants with < 34 weeks of gestational age and a weight < 2000 g, during the period from September 2017 to July 2018. We analyzed risk factors such as gestational age, birth weight, treatment with oxygen, sepsis, blood transfusion, surfactant use, postnatal steroid use, respiratory distress syndrome, multiple pregnancy, bronchopulmonary dysplasia, patent ductus arteriosus, intra- ventricular hemorrhage, and apnea episodes. We analyzed continuous and categorical variables, performed a univariate lo- gistic regression, and calculated a multivariate logistic regression model. Results: Ninety-one premature patients were studied from which 27 had ROP (29.6%). ROP incidence was greater in patients weighing < 1300 g or with a gestational age < 29 wee- ks. We found a significant risk association with sepsis (Odds ratio [OR] 8.48, 95% confident interval [CI] 3.07-23.44), gesta- tional age ≤ 29 weeks (16.3,95% CI 4.06-65.34), and birth weight < 1000 g (OR 11.25,95% CI 2.89-43.8). Conclusions: This study demonstrates that the main risk factors for ROP are sepsis, gestational age, and birth weight. A gestational age < 29 weeks and a birth weight < 1000 g are particularly important. In a multivariate logistic regression model, sepsis and gestational age were the main factors associated with ROP. It is important to evaluate all newborns with a gestational age ≤ 34 weeks and/or weighing < 1750 g, with particular emphasis to smaller newborns. Key words: Retinopathy of prematurity. Incidence. Risk factors. Resumen Objetivo: Determinar la incidencia de retinopatía del prematuro (ROP) y analizar los principales factores de riesgo en la población de recién nacidos prematuros del Hospital Lic. Adolfo López Mateos. Método: Se realizó un estudio prospectivo en el que se incluyeron prematuros con edad ≤ 34 semanas de gestación (SDG), con peso ≤ 2,000 g, durante el periodo Correspondence: *Dora A. Ochoa-Araujo Fundación H. Nuestra Señora de la Luz, Ezequiel Montes, 135 Col. Tabacalera, Del. Cuauhtemoc C.P. 06030, Mexico City, Mexico E-mail: alineochoaa@gmail.com *Oscar Medina-Contreras E-mail: omedina@himfg.edu.mx Available online: 01-11-2019 Rev Mex Oftalmol (Eng). 2019;93(6):279-285 www.rmo.com.mx Date of reception: 05-04-2019 Date of acceptance: 30-07-2019 DOI: 10.24875/RMOE.M19000088 2604-1731/© 2019 Sociedad Mexicana de Oftalmología. Published by Permanyer México SA de CV. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). No part of this publication may be reproduced or photocopying without the prior written permission of the publisher. © Permanyer 2019