Accepted Manuscript Antiproliferative effect, cell cycle arrest and apoptosis generation of novel syn- thesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene Fawzia F. Alblewi, Rawda M. Okasha, Zainab M. Hritani, Hany M. Mohamed, Mohammed A.A. El-Nassag, Ahmed H. Halawa, Ahmed Mora, Ahmed M. Fouda, Mohammed A. Assiri, Al-Anood M. Al-Dies, Tarek H. Afifi, Ahmed M. El-Agrody PII: S0045-2068(18)31494-9 DOI: https://doi.org/10.1016/j.bioorg.2019.03.059 Reference: YBIOO 2885 To appear in: Bioorganic Chemistry Received Date: 17 December 2018 Revised Date: 14 February 2019 Accepted Date: 19 March 2019 Please cite this article as: F.F. Alblewi, R.M. Okasha, Z.M. Hritani, H.M. Mohamed, M.A.A. El-Nassag, A.H. Halawa, A. Mora, A.M. Fouda, M.A. Assiri, A.M. Al-Dies, T.H. Afifi, A.M. El-Agrody, Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H- benzo[h]chromene, Bioorganic Chemistry (2019), doi: https://doi.org/10.1016/j.bioorg.2019.03.059 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.