1450 https://oamjms.eu/index.php/mjms/index Scientifc Foundation SPIROSKI, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2022 Nov 04; 10(B):1450-1452. https://doi.org/10.3889/oamjms.2022.10378 eISSN: 1857-9655 Category: B - Clinical Sciences Section: Neurology The Efect of Listening to Quran Recitation on Score of Post-Stroke Fatigue in Acute Ischemic Stroke Patients Meyvita Silviana 1 *, Naili Sof Riasari 1 , Farah Febriyani Mantikha 2 1 Department of Neurology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia; 2 Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia  Abstract BACKGROUND: One of the common stroke complications is post-stroke fatigue (PSF) with the prevalence of 25–85%. PSF infuences health-related quality of life, disability, dependence in daily activities, ability to return to work, and case fatality rate of stroke patients. Listening to Quran recitation can increase alpha waves in the brain, reduce stress and infammatory biomarkers. AIM: The purpose of this study was to identify the efect of listening to Quran recitation on PSF and fnd out the mean Fatigue Assessment Scale (FAS) score in acute ischemic stroke patients. METHODS: This was an experimental study with one-group pretest-posttest design. Sixteen subjects were recruited by consecutive sampling in Sultan Agung Islamic Hospital, Semarang. The FAS score was assessed on the 1st day of study, then Quran recitation was played 2 sessions a day, 15 min/session, for 5 days. The FAS score was reassessed on the last day. The study was conducted from August to September 2021. The analysis test used was paired t-test. RESULTS: The results showed a signifcant relationship between listening to Quran recitation with changes in FAS score in acute ischemic stroke patients (p < 0.05). Most of the subjects were <65 years old, male, had hypertension, did not have DM, and did not smoke. CONCLUSION: Listening to Quran recitation had an efect on changes in FAS score. Edited by: Mirko Spiroski Citation: Silviana M, Riasari NS, Mantikha FF. The Efect of Listening to Quran Recitation on Score of Post-Stroke Fatigue in Acute Ischemic Stroke Patients. Open-Access Maced J Med Sci. 2022 Nov 04; 10(B):1450-1452. https://doi. org/10.3889/oamjms.2022.10378 Keywords: Post-stroke fatigue; Quran recitation; Fatigue Assessment Scale *Correspondence: Meyvita Silviana, Department of Neurology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia. E-mail: drmeyvita.spn@gmail.com Received: 10-Jun-2022 Revised: 04-Sep-2022 Accepted: 25-Oct-2022 Copyright: © 2022 Meyvita Silviana, Naili Sof Riasari, Farah Febriyani Mantikha Funding: This research did not receive any fnancial support Competing Interest: The authors have declared that no competing interest exists Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial 4.0 International License (CC BY-NC 4.0) Introduction Stroke has long-term adverse consequences globally. One of the common stroke complications is post-stroke fatigue (PSF) [1]. The prevalence varies from 25% to 85%. It also afects health-related quality of life [2], more severe disability [3], dependence to perform daily activities [4], inability of patients under 60 years to return to work after sufering a stroke [5], and a higher case fatality rate in stroke patients [4]. The mechanism of PSF is still unknown. Factors such as changes in cortical excitability, lesion site, infammation, immune response, and genes are related to PSF mechanism. The role of infammation in the pathogenesis of PSF is implied in several important ways. First, fatigue is a common symptom in patients with immune-mediated disease. Second, fatigue occurs in healthy individuals who have an infection. Third, administration of pro-infammatory cytokines to healthy individuals leads to the perception of fatigue. Finally, modulation of infammation with cytokine antagonists improves fatigue in several diferent diseases. Assessment of the genetic contribution to PSF is characterized by the presence of single-nucleotide polymorphisms in genes that modulate infammation associated with PSF. PSF is associated with the IL1RN rs4251961 C allele [6]. Listening to Quran recitation can reduce stress levels [7], [8], [9], reduce cortisol serum [10] and IL-6 [11] levels, and increase alpha waves in the brain [7]. Spirituality is a protective factor in dealing with stress [12]. Music therapy in general also has an efect in reducing fatigue in several diseases [13]. Indonesia is a country with a majority Muslim population. Thus, listening to Quran recitation can be used as an easy, inexpensive, and non-invasive complementary therapy. However, the research in this feld is still limited. Therefore, the purpose of this study was to determine the efect of listening to Quran recitation on changes in Fatigue Assessment Scale (FAS) score and to fnd out the mean FAS score in acute ischemic stroke patients before and after treatment. The hypothesis in this study is that there is an efect of listening to Quran recitation on changes in FAS score which is statistically signifcant. Methods This was an experimental study with one-group pretest-posttest design. It was conducted at Sultan Agung Islamic Hospital, Semarang, for 3 months. There were 16 samples that were selected using consecutive sampling. Since 2002