ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2022, Vol. 38, No.(3): Pg. 688-697 This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC- BY). Published by Oriental Scientifc Publishing Company © 2018 A Comprehensive Review on Medicinal Plants against Lung Cancer BALAMURUgAN PANdIYAN 1 , SANgILIMUTHU ALAgAR YAdAv 1 *, KARPAgAvALLI M 2 , gAYATHIRI E 3 , SUvATHIKA gNANASELvAN 1 and SOwMYA PRIYA MANOHARAN 1 * 1 Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore–641 021, Tamil Nadu, India. 2 Karpagam College of Pharmacy, Coimbatore-641032, Tamil Nadu, India. 3 Department of Botany, Gurunanak College, Chennai, Tamilnadu, India. *Corresponding author E-mail: smuthu.al@gmail.com http://dx.doi.org/10.13005/ojc/380320 (Received: April 20, 2022; Accepted: June 10, 2022) ABSTRACT Lung cancer is a disease with a high probability of occurrence as well as a high mortality rate. Despite the fact that numerous therapies are available, a huge number of patients die each year as a result of cancer. The rising research direction in health care pharmacy paves the way for the development of an effective and side effect-free anticancer medicine. Chemical entities found in plants are extremely useful in cancer studies. Most notary bioactive phytochemicals are preferred because they act differently only on cancer cells exclusively and not normal cells. Carcinogenesis is a multi-step process that involves numerous signaling events. Phytochemicals have a pleiotropic activity which can target these events in a variety of ways, making them an excellent choice for anticancer medication therapy. Efforts are underway to create lead candidates derived from phytochemicals that can reduce the progression of cancer without inducing any side effects. The purpose of this review is to provide information on medicinal plants that have anticancer effect against lung cancer. Keywords: Medicinal plant, Secondary metabolites, Antitumor activity, Lung cancer and Phytochemicals. INTROdUCTION Cancer is a deadly disease characterized by aberrant cell proliferation. It is the leading cause of death and morbidity worldwide, with the number of cases increasing over time 1 . This disease is the second biggest cause of death in affuent countries, after cardiovascular disease 2,3 . Uncontrolled proliferation and dedifferentiation of a normal cell characterize the cancer phenomena 4 . Changes in various cellular signaling pathways link cancer to a category of hereditary illnesses 5 . The illusion of uncontrollable cell expansion reductions in apoptosis is one of the main alterations that determine malignant development 6 . The lifestyle changes are the most common cause of cancer, there is an urgent need to fnd a better cure for the condition. Because of the high mortality and occurrence, it has become