1507 A RTÍCULO DE I NVESTIGACIÓN La insulinoterapia intensificada más antineuríticos es superior a antineurítico puro en neuropatía diabética dolorosa M Juliana Bastías A, Luis Toro C a , Pablo Olmos C. Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy Background: The basis of the treatment of painful diabetic neuropathy is the use of drugs that block the transmission of pain (antineuritics) and a good metabolic control of underlying disease. Aim: To describe the outcomes of 17 type-2 diabetics with painful neuropathy, treated between 1988 and 2005 with symptomatic therapy plus intensified insulin. Material and methods: Review of medical records of 17 type-2 diabetic patients, aged 63 –11 years and a duration of diabetes of 15–8 years. All patients received intensified insulin therapy with 0.35 units/kg of NPH insulin (2/3 before breakfast and 1/3 evening meal), plus capillary glucose measurements and regular insulin (with sliding-scale centered in ~0.1 units/kg) before the 3 main meals. All patients were also treated with gabapentin, nortriptyline or clomipramine. Pain was assessed using a visual analog score of 10 points. Results: After 1 year, glycosilated hemoglobin decreased from 10.0–1.4% to 7.7–1.2% (p~=0.003). Pain decreased from 10 to 5.1–3.3 at one month, 2.3–3.2 at six months, and 3.1–3.6 at 1 year (p <0.01). There was a direct statistical correlation between the reduction of HbA1C and pain decline (r =0.736; p =0.037). Pain scores were lower than those reported elsewhere for Pregabalin (n =76; p =0.05), Lamotrigine (n =27; p <0.0005), Topiramate (n =208; p <0.005), and Gabapentin (n =84; p <0.025). The lack of difference to Sodium Valproate (n =21; p =0.07) had borderline significance. Conclusions: The addition of intensified insulin therapy to the symptomatic treatment of painful neuropathy in type-2 diabetics, significantly enhanced the reduction of pain. The lowering of glycosilated hemoglobin was a significant predictor of success in pain reduction (Rev Méd Chile 2006; 134: 1507-15). ( Key words: Diabetic neuropathies; Gabapentin; Hemoglobins; Insulin, long-acting) Recibido el 13 de enero, 2006. Aceptado el 4 de mayo, 2006. Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Uni- versidad Católica de Chile, Santiago, Chile. a Alumno de Medicina. Rev Méd Chile 2006; 134: 1507-1515 Correspondencia a: Dr. Pablo Olmos Coelho. Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile. Alameda 340, Santia- go 6513492, Santiago. Fono: 56-2-3543863; Fax: 56-2-6338298. E mail: polmos@med.puc.cl