ORIGINAL ARTICLE Bali Medical Journal (Bali Med J) 2019, Volume 8, Number 2: 337-341 P-ISSN.2089-1180, E-ISSN.2302-2914 337 Open access: www.balimedicaljournal.org and ojs.unud.ac.id/index.php/bmj CrossMark Published by DiscoverSys ABSTRACT Background: Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus (HIV) infection and characterized by a progressive decrease in the immune system function which eventually leads to the development of opportunistic infections and other complications. In order to monitor the disease progression the CD4 examination and additional Complete Blood Count (CBC) were commonly used. Objectives: To determine the correlation of total lymphocyte count, hemoglobin level, lymphocyte/leukocyte ratio (LLR) and lymphocyte/ neutrophil ratio (LNR) to CD4 levels in patients with HIV infection. Methods: This a retrospective cross-sectional analytic study conducted from July to August 2017. The total lymphocyte count, hemoglobin level, lymphocyte/leukocyte ratio (LLR) and lymphocyte/neutrophil ratio (LNR) and CD4 level were measured in the study. The data normality and the correlation were analyzed using the Kolmogorov-Smirnov test and the Pearson Correlation test, respectively, performed in SPSS version 14. The p-value less than 0.05 was considered significant for the results. Results: A total of 60 samples conducted CD4 and complete blood counts (CBC) examinations during the period July-August 2017. The mean CD4 levels were 341.73 ± 243.48 cells/μL, the total leukocyte count was 6.98 ± 2.93 x 10 3 /μL, the total lymphocyte count was 2.09 ± 0.87 x 10 3 /μL, hemoglobin level 13.38 ± 2.09 g/dL, lymphocyte/ leukocyte ratio (LLR) 0.31 ± 0.11, lymphocyte/neutrophil ratio (LNR) 0.67 ± 0.40. Statistical analysis showed that data is normally distributed. Pearson correlation analysis showed that there was a significant relationship between CD4 levels with total lymphocytes counts, hemoglobin levels, RLL, RLN with correlation coefficients of 0.571 (p = 0.000), 0.324 (p = 0.012), 0.509 (p = 0.000), 0.463 (p = 0.006), respectively. There was no significant correlation between CD4 levels and total leukocytes with a correlation coefficient of 0.171 (p = 0.19). Conclusion: There is a positive correlation between CD4 levels and total lymphocytes, hemoglobin levels, RLL and RLN in patients with HIV at Sanglah Hospital. Keywords: CD4 levels, HIV infection, complete blood counts. Cite this Article: Wande, I.N., Fuadi, M.R., Hadi, S. 2019. The Correlation between total lymphocyte count, hemoglobin levels, lymphocyte/ leukocyte ratio (LLR), and lymphocyte/neutrophil ratio (LNR) to CD4 levels in patients with Human Immunodeficiency Virus infection at Sanglah Hospital. Bali Medical Journal 8(2): 337-341. DOI:10.15562/bmj.v8i2.1408 The Correlation between total lymphocyte count, hemoglobin levels, lymphocyte/leukocyte ratio (LLR), and lymphocyte/neutrophil ratio (LNR) to CD4 levels in patients with Human Immunodeficiency Virus infection at Sanglah Hospital I Nyoman Wande, 1* Muhamad Robi’ul Fuadi, 2 Solichul Hadi 2 BACKGROUND From January to March 2017 the number of HIV infections reported was 10.376 people. Te highest percentage of HIV infections was reported in the age group 25-49 years (69,6 %), followed by the age group 20-24 years (17.6%), and the age group ≥ 50 years (6.7%). Te HIV ratio between men and women is 2:1. Te highest percentage of HIV risk factors was in homosexuals (28%), heterosexuals (24%), others (9%) and the use of non-sterile needles (2%). Te number of AIDS during January to March 2017 was reported as 637 people with the highest percentage of AIDS in the 30-39 years age group (38.6%), followed by the age group 20-29 years (29.3%) and the age group 40-49 year (16.5%). Te AIDS ratio between men and women is 2: 1. Te highest percentage of AIDS risk factors is risk sex for heterosexuals (67%), homosexuals (23%), peri- natal (2%) and use of nonsterile needles (2% ). 1 HIV infection has afected around 60 million people to date. In 2009, 33.3 million people were living with HIV worldwide; 2.6 million new cases were presented, and 1.8 million deaths were due to AIDS in the same year. In 2009, Sub-Saharan Africa was the world’s leading region for deaths caused by AIDS, carrying 1.3 million cases. Even though AIDS is a global problem, countries with fewer resources have a greater impact. 2,3 HIV is a retrovirus that mainly afects T cells and cells that express CD4, such as macrophages, folli- cle dendritic cells, and lymph nodes. In a history of natural HIV infection, there is an initial decrease in TCD4 lymphocyte count associated with primary 1 Clinical Pathology Department, Medical Faculty, Udayana University / Sanglah Hospital, Bali, Indonesia 2 Clinical Pathology Department, Medical Faculty, Airlangga University/Dr. Soetomo Hospital, Surabaya, Indonesia * Correspondence to: I Nyoman Wande; Clinical Pathology Department, Medical Faculty, Udayana University / Sanglah Hospital, Bali, Indonesia wandenyoman@gmail.com Received: 2018-12-01 Accepted: 2019-04-01 Published: 2019-08-01