Identification of potential molecular target of hypertension from Allium schoenoprasum by using network pharmacology and molecular docking strategies Aditya Trias Pradana 1 , Ginda Haro 2 , Novarianti Marbun 3 , Sofia Rahmi 3 , Iksen Iksen 4 1 Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia 3 Faculty of Pharmacy, Institut Kesehatan Deli Husada, Deli Tua, Indonesia 4 Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Senior Medan, Medan, Indonesia Corresponding author: Iksen Iksen (ikseniksen08@gmail.com) Received 6 February 2023  ♦  Accepted 9 May 2023  ♦  Published 31 August 2023 Citation: Trias Pradana A, Haro G, Marbun N, Rahmi S, Iksen I (2023) Identifcation of potential molecular target of hypertension from Allium schoenoprasum by using network pharmacology and molecular docking strategies. Pharmacia 70(3): 699–706. https:// doi.org/10.3897/pharmacia.70.e101537 Abstract Hypertension is one of the silent killers in human life which is characterized by uncontrolled blood pressure. Although many thera- peutic drugs have demonstrated success in treating hypertension, these treatments have their own drawbacks, most notably in terms of cost and side efects. Hypertension treatment with natural products has lately been proposed. Tis study focused on the potential of Allium schoenoprasum against hypertension based on network pharmacology and molecular docking strategies. Interested com- pounds and targets were identifed by searching accessible databases. Protein-protein interaction (PPI), Gene ontology (GO), and Kyoto encyclopedia of genes and genomes (KEGG) were conducted to determine the potential targets from Allium schoenoprasum. In this study, 10 potentially active compounds were obtained. PPI results showed SCR, STAT3, PIK3R1, CTNBB1, and ESR1 as the main targets of hypertension. GO and KEGG investigation confrmed the PPI targets are mainly involved in protein binding and catalytic in the membrane and cytoplasm. In the end, by using molecular docking, kaempferol, isorhamnetin, and quercetin showed the most potent compounds in Allium schoenoprasum against hypertension. In summary, Allium schoenoprasum exhibited antihy- pertensive activity via network pharmacology and molecular docking approaches. Keywords Hypertension, Allium schoenoprasum L., network pharmacology, molecular docking Introduction One of the diseases that is one of the most dangerous to human health and has a high incidence rate all over the world is hypertension. Te number of people who have been diagnosed with hypertension continues to rise on an annual basis, and it is anticipated that the number of peo- ple who have been diagnosed with hypertension will reach almost 2 billion by the year 2025 (Mills et al. 2020). A rel- atively small percentage of patients with hypertension can have their condition properly managed once the disease has already manifested itself. Hypertension is harmful Copyright Trias Pradana A et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Pharmacia 70(3): 699–706 DOI 10.3897/pharmacia.70.e101537 Research Article