Accepted Manuscript Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action Daniel Scheps, Manuela López de la Paz, Marcel Jurk, Fred Hofmann, Jürgen Frevert PII: S0041-0101(17)30279-9 DOI: 10.1016/j.toxicon.2017.09.006 Reference: TOXCON 5718 To appear in: Toxicon Received Date: 1 June 2017 Revised Date: 24 August 2017 Accepted Date: 9 September 2017 Please cite this article as: Scheps, D., de la Paz, Manuela.Ló., Jurk, M., Hofmann, F., Frevert, Jü., Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action, Toxicon (2017), doi: 10.1016/j.toxicon.2017.09.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.