Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis Juliana Y Sakita 1 , Michael Bader 2,3,4 , Emerson S. Santos 1 , Sergio B Garcia 6 , Stefania B Minto 6 , Natalia Alenina 2,5 , Mariângela O Brunaldi 6 , Milene C Carvalho 7 , Thiago Vidotto 8 , Bianca Gasparotto 1 , Ronaldo B. Martins 9 , Wilson A. Silva Jr 8 , Marcus L Brandão 7 , Caio A Leite 10 , Fernando Q Cunha 10 , Gerard Karsenty 11 , Jeremy A Squire 8,12 , Sergio A Uyemura 1 , Vinicius Kannen 1 * 1 Department of Toxicology, Bromatology, and Clinical Analysis, University of Sao Paulo, Ribeirao Preto, Brazil; 2 Max-Delbrück-Center for Molecular Medicine, Berlin, Germany; 3 Charité, University Medicine Berlin, Germany; 4 Berlin Institute of Health (BIH), Berlin, Germany; 5 Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; 6 Department of Pathology, University of Sao Paulo, Ribeirao Preto, Brazil; 7 Faculty of Philosophy, Sciences and Letters, University of São Paulo, Ribeirao Preto, Brazil; 8 Department of Genetics, University of Sao Paulo, Ribeirao Preto, Brazil; 9 Department of Cell and Molecular Biology, Virology Research Center, University of Sao Paulo, Ribeirao Preto, Brazil; 10 Department of Pharmacology, University of Sao Paulo, Ribeirao Preto, Brazil; 11 Department of Genetics and Development, Columbia University, New York, United States; 12 Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada. Running Head: Serotonin and colorectal cancer. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/path.5285 Accepted Article This article is protected by copyright. All rights reserved.