BP I Bulletin of Integrative Psychiatry Buletin de Psihiatrie Integrativa Effects of gonadotropins in female infertility associated with depression Roxana Mihaela Barbu, Cristina-Maria Gavrilescu, Bogdan Stana, Răducu Ionuț Popescu, Pohaci-Antonesei Catalin, Walther Bild Roxana Mihaela Barbu - MD, PhD, Department of Physiology, University of Medicine and Pharmacy ,,Grigore T. Popa”, Iași, Specialist in Clinical Pharmacology, Romania Cristina-Maria Gavrilescu - Lecturer, MD, PhD, „Grigore T. Popa” University of Medicine and Pharmacy, Iași, Ist Medical Department, Iași, Romania, senior in Internal Medicine, specialist în Geriatrics, specialist în Clinical Pharmacology Bogdan Stana - Lecturer, MD, PhD, „Grigore T. Popa” University of Medicine and Pharmacy, Iași, Specialist in Pediatrics, Romania. Răducu Ionuț Popescu - MD, PhD, Department of Physiology, University of Medicine and Pharmacy ,,Grigore T. Popa”, Iași, Romania. Pohaci-Antonesei Catalin - MD, PhD, Department of Physiology, University of Medicine and Pharmacy ,,Grigore T. Popa”, Iași, Specialist in Occupational Medicine, Romania. Walther Bild - MD, PhD, Professor Department of Physiology, University of Medicine and Pharmacy ,,Grigore T. Popa”, Iași, Romania. ABSTRACT Introduction: The relationship between LH and FSH changes and mental health is not clear yet, but may be independent of a strict diagnosis of infertility. Ongoing research has suggested that testosterone levels may play a role in brain development, which could provide a possible explanation for this association. Healthcare providers caring for women with infertility need to be aware that their patients may face many challenges when faced with infertility, such as depression. An in-depth assessment of the psychiatric needs of patients with infertility is crucial to provide specialized care to this category of patients. The aim of the study was to observe the possible implications of FSH and LH hormones in infertility and associated depression through studying the hormone levels in two Swiss mice groups and to compare these findings to the current literature. Materials and Methods: We used 20 Swiss nulliparous female mice and 15 Swiss multiparous female mice and we measured the luteinizing hormone and follicle-stimulating hormone in each group. Results: We observed a significant increase in mean LH and FSH in the multiparous group compared to the nulliparous group. In conclusion, significant differences in LH and FSH în the multiparous group compared to the nulliparous group and the presence of variations between the two groups of the studied mice