the source of emboli) may require extensive and time-consuming diagnostic setting. Objective: To evaluate whether the admission elevation of serum cardiac markers (CM) in young acute IS patients may be associated with the presence of relevant cardiac source of emboli. Methods: The study set consisted of acute IS patients b 50 years enrolled in the prospective HISTORY (Heart and Ischemic STrOke Relationship studY) study. In all patients, brain ischemia was confirmed on CT/MRI. Admission ECG, serum CM (N-terminal pro- brain natriuretic peptide and high sensitive Troponin T), trans- oesophageal echocardiography (TEE), 24-hour and 3-week ECG- Holter were performed in all patients. Results: Of 831 patients enrolled in the HISTORY study, 118 (62 males, mean age 40 ± 8.4 years) were b 50 years. In total, 22 (19%) patients had elevated serum CM at admission. Relevant cardiac abnormities were detected in 13 (59%) patients with elevation of serum CM and in 2 (2%) with normal level of serum CM (p b 0.0001). Atrial fibrillation including paroxysmal was detected in 10 (67%) patients, other three patients had ischemic coronary disease, one patient had severe valve defect and one patient had large acute thrombosis of ascending aorta. Conclusion: Young acute IS patients with elevated serum CM had more frequently relevant cardiac abnormities with embolic potential. Study was supported by the IGA MH CR grants NT11046-6/2010 and NT14288-3/2013 and by RVO FNOL 00098892. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT01541163. doi:10.1016/j.jns.2015.08.1443 1409 WFN15-0489 Stroke Cardioembolic etiology of acute ischemic stroke in patients indicated to revascularization D. Sanak a , M. Kral a , M. Hutyra b , T. Veverka a , T. Dornak a , D. Vindis b , A. Bartkova a , D. Skoloudik c , M. Taborsky b , P. Kanovsky a . a Department of Neurology, University Hospital Olomouc, Olomouc, Czech Republic; b Department of Cardiology, University Hospital Olomouc, Olomouc, Czech Republic; c Department of Nursing, Faculty of Health Sciences Palacký University, Olomouc, Czech Republic Background: Incidence of cardioembolic stroke (CS) is still consid- ered being underestimated, because reliable detection requires extensive and time-consuming diagnostic setting. Objective: Aim was to assess cardioembolic etiology of acute ischemic stroke (IS) in patients admitted for revascularization. Methods: In this prospective study (Clinicaltrials.gov No. NCT01541163), 535 (314 males, mean age 68.4 ± 12.3 years) consecutive acute IS patients were enrolled within first 6 h after stroke onset. CT/MRI, laboratory tests, repeated ECG, 24 h ECG Holter monitoring, transthoracic and transoesophageal echocardiography, and ultrasound of cervical and intracranial arteries were performed in all patients. Etiology of IS was assessed using the TOAST and ASCOD classifications. Demographic and baseline clinical parameters were compared between cardioembolic (ASCOD C1) and non-cardioembolic (ASCOD C0) strokes. Results: According to the TOAST; 228 (42.6%) patients were identified as CS. According to the ASCOD; 243 (45.4%) patients were classified as C1 (potentially causal). Atrial fibrillation (AF) was detected in 208 (85.6%); in 119 (57.2%) patients was newly diagnosed. Other cause of car- dioembolism was present in 35 (14.4%) patients. Patients with CS were significantly older (72.4 vs. 56.1 years, P b 0.001) and admitted earlier (102 vs. 126 min, P = 0.005) than patients with other etiology of IS. No differences was found between groups in performed revascularization (42.2% vs. 41.0% P = 0.43). Conclusions: Cardiac source of emboli was detected in 45% acute IS patients indicated to revascularization. AF was the most frequent cause; in most patients newly diagnosed. Supported by the IGA MH CR grants NT/ 11046-6/2010 and NT/14288-3/2013, and by RVO FNOl 00098892. doi:10.1016/j.jns.2015.08.1444 1412 WFN15-0984 Stroke Moya-Moya syndrome associated to falciform trait G. Saraiva, G. Santana de Lima, R. Mendes Silva, A. Bueno Carvalho, C. Fernandes Melo Alves, P. Phelipe Barbosa Monteiro, F. Moraes Cardoso Marques, M. Alexandre Diniz Carneiro, T. Alexandrino Gonçalves Jube Ribeiro, D. Sisterolli Diniz. Neurology, University Federal of Goias, Goiania, Brazil Background: The Moyamoya syndrome (MMS) is a cerebrovascular condition that predisposes affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches. This results in collateral vascularization at the base of the brain, which on cerebral angiography appears as a ‘puff of smoke’, which is termed Moya Moya in Japanese. MMS is rare and has been characterized mainly in Asian countries and represents a rare cause of stroke, in both the pediatric and adult population. May be idiopathic or may occur secondary to many disorders, including sickle cell anemia. Objectives: Report a case of MMS secondary of sickle cell trait. Patients and methods: C.H.S.D., male, 35, black, in Multiple Sclerosis (MS) monitoring for 8 years,neurological symptoms of dysarthria, dysmetria, imbalance, incoordination and gait ataxia. Brother and nephew with sickle cell anemia, cousin with MS. During follow-up, there was disagreement between the previous diagnosis of MS and the clinical presentation. Thus, it was considered the possibility of cerebrovascular disease associated with sickle cell trait, discarded other secondary causes. Angio -MR with MMS standard. Results: We reported a case of MMS associated to sickle cell trait. Conclusion: As described in the literature, there is usually presence of MMS in patients with sickle cell anemia, but there are reports of rare cases of association with sickle cell trait. We caution the importance of think this hypothesis in patients with sickle cell trait, avoiding delay in diagnosis and treatment. doi:10.1016/j.jns.2015.08.1445 1413 WFN15-0053 Stroke Intracerebral hemorrhage complication after IV thrombolytic treatment Y. Seçil, T. Mengi, A. Çoban, M. Çelebisoy, T.K. İncesu, Y. Beckmann, B. Özer, G. Akhan. Neurology, Izmir Katip Çelebi University Atatürk Education and Research Hospital, Izmir, Turkey Background: Intravenous thrombolytic treatment with recombinant tissue plasminogen activator (rt-PA) is efficacious methods for ischemic stroke patients in first 4.5 hours. After iv rt-PA thrombolytic treatment, symptomatic intracerebral hemorrhage (ICH) rate is 6%, fatal ICH rate is 3%. Objective: We planned to find out our ICH complication rate after iv thrombolytic treatment and to determine the factors affecting this complication. Abstracts / Journal of the Neurological Sciences 357 (2015) e363–e423 e409