Open Access Research Article Journal of Regenerative Medicine & Biology Research Colli M | Volume 3; Issue 1 (2022) | JRMBR-3(1)-023 | Research Article Citation: Colli M, et al. Non-surgical Jowl and Jawline Rejuvenation with Resorbable Suspension Threads and Superficial Enhanced Fluid Fat Injection (SEFFI). J Reg Med Biol Res. 2022;3(1):1-19. DOI: https://doi.org/10.46889/JRMBR.2022.3102 Non-surgical Jowl and Jawline Rejuvenation with Resorbable Suspension Threads and Superficial Enhanced Fluid Fat Injection (SEFFI) Mattia Colli 1* , Alessandro Gennai 2 , Rosalba Russo 3 , Andrea Tomeo 4 , Bruno Bovani 5 , Domenico Piccolo 6 , Fabrizio Melfa 7 , Piero Tesauro 8 , Alberto Diaspro 9 1 Podgora 7, Private Practice Via Podgora 7, Milano, Italy 2 Studio Gennai, Private Practice, Via Delle Lame 98, Bologna, Italy 3 Estemed, Private Practice, Modena, Italy 4 AMdermamedical Clinic, Private Practice, 5 Upper Wimpole Street, London, United Kingdom 5 Centro Medico Esculapio, via Angeloni 43, Perugia, Italy 6 Skin Center, Private Practice, via Napoli 17, Pescara, Italy 7 Mediaging Clinic Center, via Marchese di Villabianca 187, Palermo, Italy 8 Poliambulatorio Gioia, via Melchiorre Gioia 31, Milano, Italy 9 Rigeneralba Center for Regenerative Medicine, Turin, Italy * Corresponding Author: Mattia Colli. Podgora 7, Private Practice Via Podgora 7, Milano, Italy; Email: mattiacolli@shbclinic.com Received Date: 23-03-2022; Accepted Date: 08-04-2022; Published Date: 15-04-2022 Copyright © 2022 by Colli M, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Abstract Background: Collagen and elastin play a crucial role in skin traction; their deterioration contributes to causing skin sagging and laxity with time. Soft tissue ptosis modifies the mandibular profile in addition to enhancing the nasolabial folds, lines of puppets and lateral eyebrow area; moreover, skin atrophy and volume loss are major factors involved in facial aging, contributing to the formation of facial rhytids, skeletonization, and pseudo-descent of